產(chǎn)品編號(hào) | bs-23753R-Cy5 |
英文名稱 | Rabbit Anti-Cyclin E2/Cy5 Conjugated antibody |
中文名稱 | Cy5標(biāo)記的周期素E2抗體 |
別 名 | CCN E2; CCNE 2; CCNE2; CCNE2 protein; CYC E2; CYCE 2; CYCE2; CyclinE2; G1/S-specific cyclin E2; G1/S-specific cyclin E2; CCNE2_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 44kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Cyclin E2 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells. Subunit: "Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Subcellular Location: Nucleus. Tissue Specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. Post-translational modifications: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway. Similarity: Belongs to the cyclin family. Cyclin E subfamily. Database links: Entrez Gene: 9134 Human Entrez Gene: 12448 Mouse Omim: 603775 Human SwissProt: O96020 Human SwissProt: Q7TMS8 Mouse SwissProt: Q9Z238 Mouse Unigene: 567387 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 亚洲有码在线观看 | 亚洲∧V久久久无码精品触手 | 无码人妻精品一区二区三区千菊 | 91精品国产高清久久久久久g | 富婆鸭子一区二区三区 | 后入内射欧美99二区视频 | 国产美女碳化酒店激情啪啪 | 亚洲午夜精品一区二区三区他趣 | 欧美一级高清片国产特黄大片 | 国内精品国产成人三级 | 西西www4444人妻视频 | 亚洲国产精品成人做爰A片 粉嫩av浪潮av色欲aV | 探花视频一区二区三区高清免费在线观看 | 色情大片AAAAAA视频 | 少妇被大狼拘躁A片免费 | 搡老女人51妇女老熟女 | 古装妇婬A片AA毛A片 | 国产65一二三区 | 国产又爽又大又黄A片色戒一 | 安徽妇搡BBBB搡BBBB小说 | 中文字幕av在线观看 | 中字无码在线电影资源 | 精品人妻码一区二区三区剧情 | 特级做a爰片毛片免线看在线 | 亚洲视频第一页视频 | 国产伦亲子伦亲子视频观看 | 欧美激情在线播放 | 永久免费看mv网站入口亚洲 | 丰满人妻的婬乱生活2 | 国产欧美综合 激情 | 激情综合网激情五月天 | 一级卖婬片A片AAAA鲁大师 | 亚欧成a人无码精品vA片 | 老熟女多毛一区二区三区四区五区 | 成人性做爰全过程免费 | 国产精品无码人妻无码色情多人 | 91探花国产综合在线精品 | 国产成人网站p站在线播放 黄色视频在线观看澳洲精品 | 免费无码婬片AAAA片直播 | 蜜桃秘 无码一区二区三区四区 |