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Rabbit Anti-DHRS11/AP Conjugated antibody (bs-18921R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18921R-AP
英文名稱 Rabbit Anti-DHRS11/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的DHRS11蛋白抗體
別    名 MGC4172; ARPG836; Dehydrogenase/reductase (SDR family) member 11; Dehydrogenase/reductase SDR family member 11; Dehydrogenase/reductase SDR family member 11 precursor; DHR11_HUMAN; DHRS11; FLJ39232; SDR24C1; short chain dehydrogenase/reductase; Short chain dehydrogenase/reductase family 24C, member 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DHRS11
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
DHRS11 is a 260 amino acid secreted protein. Belonging to the short-chain dehydrogenases/reductases (SDR) family, DHRS11 forms a homotetramer and is expressed as two isoforms produced by alternative splicing events. The gene that encodes DHRS11 maps to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Subcellular Location:
Secreted.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Database links:

Entrez Gene: 395172 Chicken

Entrez Gene: 491129 Dog

Entrez Gene: 79154 Human

Entrez Gene: 192970 Mouse

Entrez Gene: 360583 Rat

SwissProt: Q6UWP2 Human

SwissProt: Q3U0B3 Mouse

Unigene: 462859 Human

Unigene: 192213 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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