| 產(chǎn)品編號 | bs-17277R-AP |
| 英文名稱 | Rabbit Anti-Scavenger Receptor BI + BII/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的清道夫受體B1+B2抗體 |
| 別 名 | 85 kDa lysosomal membrane sialoglycoprotein; CD36 and LIMPII Analogous 1; CD36L1; CD36L2; CLA1; HLGP85; LGP85; LIMP II; Lysosome membrane protein II; MGC138242; SCARB1; SCARB2; Scavenger receptor class B member 2; Scavenger Receptor Class B Type I; SRBI; SRBII. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細胞生物 信號轉(zhuǎn)導(dǎo) 細胞膜受體 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Scavenger Receptor BI + BII |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] Function: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells. Subcellular Location: Lysosome; lysosomal membrane; multi-pass membrane protein. Database links: Entrez Gene: 949 Human Entrez Gene: 950 Human Entrez Gene: 12492 Mouse Entrez Gene: 20778 Mouse Omim: 601040 Human Omim: 602257 Human SwissProt: Q14108 Human SwissProt: Q8WTV0 Human SwissProt: O35114 Mouse SwissProt: Q61009 Mouse Unigene: 298813 Human Unigene: 349656 Human Unigene: 592984 Human Unigene: 282242 Mouse Unigene: 297964 Mouse Unigene: 399507 Mouse Unigene: 410528 Mouse Unigene: 3957 Rat Unigene: 88169 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
