產(chǎn)品編號 | bs-16322R-BF350 |
英文名稱 | Rabbit Anti-phospho-GRLF1(Tyr1087)/BF350 Conjugated antibody |
中文名稱 | BF350標(biāo)記的磷酸化糖皮質(zhì)激素受體DNA結(jié)合因子1抗體 |
別 名 | GRLF1 (phospho Y1087); p-GRLF1 (phospho Y1087); ARHGAP35; GAP associated protein p190; Glucocorticoid receptor DNA binding factor 1; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; Glucocorticoid receptor repression factor 1; GRF 1; GRF-1; GRF1; GRLF 1; GRLF1; GRLF1_HUMAN; KIAA1722; MGC10745; p190 A; p190-A; P190A; P190A, rat, homolog of; p190ARhoGAP; p190RhoGAP; Rho GAP p190A; Rho GAP p190A; Rho GTPase-activating protein 35. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 171kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human GRLF1 around the phosphorylation site of Tyr1087 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] Function: Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Tyrosine phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 4 FF domains. Contains 1 Rho-GAP domain. Database links: Entrez Gene: 2909 Human Entrez Gene: 232906 Mouse Omim: 605277 Human SwissProt: Q9NRY4 Human SwissProt: Q91YM2 Mouse Unigene: 509447 Human Unigene: 28646 Mouse Unigene: 400358 Mouse Unigene: 16508 Rat Unigene: 222475 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 亚洲自偷拍精喷四虎 | 丝袜被扒在线观看网站 | 久久国产精品视频 | 色黄大色黄女片免费看直播 | 日本少妇AA一级特黄大片 | 国产人妻无码一区二区三区不卡 | A片试看120分钟做受视频在线 | 免费在线观看黄片 | 69精品丰满人妻无码视频A片 | 亚洲国产精品无码久久一线夕不卡 | 羞羞视频在线播放 | 国产麻豆乱码精品一区二区三区 | 国产寡妇婬乱A片AAA毛片 | 国产精品久久久久影院老司 | 超碰爆艹乱伦黑人巨吊艹大逼 | 少妇的肉体AAAAA免费视频 | 久久久精品一区二区三潘金莲 | 西西4444WWW无码视频 | 精品一区二区超碰久久久 | 奥田咲 影音先锋 亚洲一区 | 免费网站黄色在线观看 | 十五分钟高清无码视频 | 欧美成人网站免费体验 | 成人性做爰全过程免费 | 国产精品三级片久色 | 久久久久无码人妻一区二区三区 | 日本中文字幕在线 | 亚洲精品秘 一区二区三区蜜桃久 | 亚洲最新国语黄色网址 | 内射囯产旡码丰满少妇 | 亚洲一区二区在线 | 少妇与大狼拘作爱性A片 | 在线观看成人视频 | 国产精品成人在线观看 | 日欧一片内射va在线影院 | 国产老熟女精品久久久久影院黑人 | 久久人妻少妇嫩草AV蜜桃漫画 | 精品99视频免费在线观看 | 午夜精品久久无码成人 | 少妇伦子伦5在线播放 |