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Rabbit Anti-phospho-GRLF1(Tyr1087)/Gold Conjugated antibody (bs-16322R-Gold)
訂購(gòu)熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-16322R-Gold
英文名稱 Rabbit Anti-phospho-GRLF1(Tyr1087)/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的磷酸化糖皮質(zhì)激素受體DNA結(jié)合因子1抗體
別    名 GRLF1 (phospho Y1087); p-GRLF1 (phospho Y1087); ARHGAP35; GAP associated protein p190; Glucocorticoid receptor DNA binding factor 1; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; Glucocorticoid receptor repression factor 1; GRF 1; GRF-1; GRF1; GRLF 1; GRLF1; GRLF1_HUMAN; KIAA1722; MGC10745; p190 A; p190-A; P190A; P190A, rat, homolog of; p190ARhoGAP; p190RhoGAP; Rho GAP p190A; Rho GAP p190A; Rho GTPase-activating protein 35.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 171kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human GRLF1 around the phosphorylation site of Tyr1087
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Function:
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Tyrosine phosphorylated.
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 4 FF domains.
Contains 1 Rho-GAP domain.

Database links:

Entrez Gene: 2909 Human

Entrez Gene: 232906 Mouse

Entrez Gene: 306400 Rat

Omim: 605277 Human

SwissProt: Q9NRY4 Human

SwissProt: Q91YM2 Mouse

SwissProt: P81128 Rat

Unigene: 509447 Human

Unigene: 28646 Mouse

Unigene: 400358 Mouse

Unigene: 16508 Rat

Unigene: 222475 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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