| 產(chǎn)品編號(hào) | bs-13257R-APC |
| 英文名稱 | Rabbit Anti-GABA A receptor pi/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的G氨基丁酸受體pi/GABAA Rπ抗體 |
| 別 名 | GABA(A) receptor; GABA(A) receptor subunit pi; GABRP; Gamma aminobutyric acid (GABA) A receptor pi; Gamma aminobutyric acid A receptor pi; Gamma aminobutyric acid receptor pi subunit; Gamma aminobutyric acid receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi; GBRP_HUMAN; MGC126386; MGC126387; GABA A receptor pi. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABRP/GABA A receptor pi |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Subcellular Location: Cell junction; synapse; postsynaptic cell membrane. Cell membrane. Tissue Specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily. Database links: Entrez Gene: 2568 Human Entrez Gene: 216643 Mouse Omim: 602729 Human SwissProt: O00591 Human SwissProt: Q8QZW7 Mouse Unigene: 26225 Human Unigene: 99989 Mouse Unigene: 21401 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
