產(chǎn)品編號(hào) | bs-13084R-PE-Cy7 |
英文名稱 | Rabbit Anti-phospho-Ephexin-1 (Tyr179)/PE-Cy7 Conjugated antibody |
中文名稱 | PE-Cy7標(biāo)記的磷酸化神經(jīng)細(xì)胞鳥(niǎo)苷酸置換因子Ephexin1抗體 |
別 名 | Ephexin-1 (phospho Y179); p-Ephexin-1 (phospho Y179); ARHGEF27; Eph-interacting exchange protein; EPHEXIN; Ephexin 1; Neuronal guanine nucleotide exchange factor; Ngef; NGEF_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 82kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species. Function: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension. Subunit: Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Subcellular Location: Cytoplasm. Membrane. Cell projection, growth cone. Associated with membranes. Localizes to axonal growth cones. Tissue Specificity: Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. Post-translational modifications: Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain. Database links : UniProtKB/Swiss-Prot: Q8N5V2.2 Database links: Entrez Gene: 25791 Human Entrez Gene: 53972 Mouse Entrez Gene: 424744 Chicken Omim: 605991 Human SwissProt: Q8N5V2 Human SwissProt: Q8CHT1 Mouse Unigene: 97316 Human Unigene: 435439 Mouse Unigene: 20670 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 蜜臀少妇人妻精品无码 | 寡妇高潮一级寡妇房间 | 国产一起毛国产一级毛片。 | 久久AV秘 一区二区三区水牛 | 中文字幕-在线观看-黄色区 | 免费 无码 国产在线观看 | 日日夜夜免费精品视频 | 国产视频一区二区三区在线观看 | 人妻无码啪啪AAAAA | 日本青草久久老色鬼 | 婬荡欲女搡BBBB搡BBB视频 | 日本不卡在线观看 | 成a人在线观看一区红桃 | 国产成人精品无码免费看夜聊软件 | 午夜无码熟熟妇丰满人妻 | 最好看的2018免费观看在线 | 91嫖妓按摩店老熟女 | 久久久久免费毛A片免费一瓶梅 | 国产精品1区2区3区 麻豆视频一区二区三区 | 午夜免费视频在线观看 | 苍井空亚洲精品AA片在线播放 | 午夜视频免费观看 | 国产伦精品一区二区三区视频黑人 | 国产乱妇无码大黄AA片 | 东南亚一级毛片高清在线 | 精品国婬伦v无码久久久 | 风流少妇妇A片麻豆 | 亚洲有码在线观看 | 久久99国产精品1区二区 | 91久久久久久久久 | 1000部国产精品成人观看 | 麻豆精品秘 国产传媒AV消防 | 国产精品扒开腿做爽爽爽视频 | 欧美日韩国产一区二区三区 | 97精东传媒国产完整版 | 成人做爰高潮A片免费视频 真实的国产乱ⅩXXX88 | 免费黃色三級片在线观看 | 国产成人无码精品久久久久 | 日本三级吃奶头添泬无码视频网站 | 国产91久久婷婷一区二区 |