產(chǎn)品編號 | bs-13047R-Cy3 |
英文名稱 | Rabbit Anti-EBP1/Cy3 Conjugated antibody |
中文名稱 | Cy3標(biāo)記的erbB3結(jié)合蛋白1抗體 |
別 名 | AA672939; Cell cycle protein p38 2G4 homolog; Cell cycle protein p38-2G4 homolog; ErbB-3 binding protein 1; ErbB3 binding protein 1; ErbB3-binding protein 1; ErbB3-binding protein Ebp1; hG4 1; hG4-1; IRES-specific cellular trans-acting factor 45 kDa; MGC81621; MGC94070; Mpp1; p38 2G4; PA2G4; PA2G4_HUMAN; Plfap; Proliferation associated 2G4; Proliferation associated 2G4, 38-KD; Proliferation-associated 2G4, 38kDa; Proliferation-associated 2G4, a; Proliferation-associated protein 1; Proliferation-associated protein 2G4; Protein p38-2G4; si:dz150i12.2; wu:fb19b11; wu:ft56d05; zgc:86732. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 細胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Zebrafish, Sheep, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 44kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human EBP1 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: EBP1 is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is expressed in a variety of cell lines, including a wide range of tumor cell lines, and localizes to the cytoplasm. Upon treatment with Neuregulin-1 (heregulin), EBP1 translocates to the nucleus. EBP1 is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. In addition, EBP1 interacts with ErbB-3 and may function as a modulator of the ErbB-3-mediated signal transduction pathway by regulating the effects of Neuregulin-1 (heregulin). EBP1 also associates with histone deacetylases (HDACs), functioning as a transcriptional co-repressor of cell cycle regulatory genes. Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Subunit: Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Subcellular Location: Cytoplasm. Nucleus > nucleolus. Tranlocates to the nucleus upon treatment with HRG. Tissue Specificity: Expressed in several cell lines tested, including primary and transformed cell lines. Post-translational modifications: Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Similarity: Belongs to the peptidase M24 family. Database links: UniProtKB/Swiss-Prot: Q9UQ80.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产黃色A片三級三級三級四川 | 亚洲AV苍井空一区精 | 色国产精品一区在线观看 | 亚洲小说欧美激情另类A片小说 | 午夜精品A片一二三区蜜臀 无遮挡120秒试看3分钟 | 饥渴丰满少妇大力进入嗷嗷叫 | 免费无码婬片A片AAA毛扒开 | 少妇高潮毛片免费播放A片 十分钟做a小视频免费观看 | 国产寡妇婬乱A毛片视频图片 | 国产精品国产三级国产 | 色情一区二区三区四区 | 国产日韩欧美精卡不卡 | 中文字幕日韩人妻在线视频 | 老少亂伦一区二区三区 | 中文字幕av久久爽Av | 特级西西4444WWW无码 | 国产一区二区三区三州 | 91丰满熟女嗷嗷叫抽搐 | 涂了春药被一群人伦爽99式 | 色婷婷精品久久二区二区密 | 亚洲精品视频免费看 | 成人片一区二区喷水少妇 | 两个人看的www在线视频 | 久久精品在线视频网站在线视频 | 99在线无码精品秘 入口 | 欧美.亚洲.日韩.另类 | 极品粉嫩小仙女高潮喷水久久 | 一区二区中文字幕 | 好吊一区二区三区 | 亚洲日韩国产AV无码无码精品 | 中国四川农村自拍的一级免费片 | 无码人妻一区二区三区神彩美 | 在线免费观看黄色视频网站 | 蜜臀久久99精品久久久无需会员 | 国产美女鸡巴免费性爱视频 | 国内精品国产成人三级 | 91精品国产乱码久久久 | 欧美一级婬片A片无码 | 国产口爆吞精一区二区 | A片视频免费在线播放 |