| 產(chǎn)品編號(hào) | bs-5605R-AP |
| 英文名稱 | Rabbit Anti-phospho-TERT(Ser1125)/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的磷酸化端粒酶逆轉(zhuǎn)錄酶抗體 |
| 別 名 | p-TERT(Ser1125); TERT(phospho S1125); EST2; hEST2; TCS1; Telomerase associated protein 2; Telomerase Catalytic Subunit; Telomere Reverse Transcriptase; TERT; TP2; TRT. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 124kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human TERT around the phosphorylation site of Ser1125 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that TERT cooperates with HPV E7 in cell immortalization. Ever since the discovery that telomeres are short in cancer cells and telomerase is activated in immortal cells, telomerase has been associated with oncogenes. During the past year, major advances have been made in understanding the link between telomerase expression and cell immortality. Studies of yeast telomeres have revealed an unexpected role for the non-homologous end-joining machinery in telomere maintenance and have provided the first definitive evidence that telomeres play a critical role in meiosis. Identification of new telomere proteins has led to a better understanding of vertebrate telomere structure and function. Database links: Entrez Gene: 7015 Human Entrez Gene: 21752 Mouse SwissProt: O14746 Human SwissProt: O70372 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ????端粒酶逆轉(zhuǎn)錄酶hTERT是構(gòu)成端粒酶的組分之一,是端粒酶活性的必需和限速成分,其水平?jīng)Q定細(xì)胞端粒酶的活性.抑制hTERT可降低端粒酶的活性,從而抑制瘤細(xì)胞生長(zhǎng).目前對(duì)hTERT的研究已成為端粒酶研究的熱點(diǎn)問題,已發(fā)現(xiàn)TERT蛋白表達(dá)在腫瘤診斷中有重要意義,并制備了hTERT抗體及應(yīng)用核酶技術(shù)等來抑制hTERT蛋白的表達(dá),抑制端粒酶活性,從而抑制腫瘤的生長(zhǎng). ????端粒反轉(zhuǎn)錄酶又稱端粒酶催化亞單位 （hTRT；Telomerase catalytic subunit；HEST2；Telomerase-associated protein 2；TP2；Telomerase reverse transcriptase；telomerase catalytic subunit）是細(xì)胞永生化及惡性腫瘤發(fā)生過程中的端粒酶活化的主要限速步驟。hTRT基因表達(dá)可以反映端粒酶活性，與端粒酶活性具有平行關(guān)系. |
