產(chǎn)品編號 | bs-5356R-FITC |
英文名稱 | Rabbit Anti-phospho-GABBR2 (Ser783)/FITC Conjugated antibody |
中文名稱 | FITC標記的磷酸化G氨基丁酸B型受體2抗體 |
別 名 | GABA B Receptor 2 (phospho S783); p-GABA B Receptor 2 (phospho S783); GABBR2 (Ser783); p-GABBR2 (Ser783); GABBR2; GB2; G protein coupled receptor 51; G-protein coupled receptor 51; GAB B R2; GABA B R2; GABA B receptor 2; GABA B RECEPTOR; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABA[[B]]R2; GABAB R2; GABABR 2; GABABR2; GABB R2; GABBR 2; Gabbr2; GABR2_HUMAN; Gamma aminobutyric acid (GABA) B receptor 2; Gamma aminobutyric acid B receptor 2; Gamma aminobutyric acid GABA B receptor 2; Gamma aminobutyric acid type B receptor subunit 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb 2; Gb2; GH07312; GPR 51; GPR51; GPRC 3B; GPRC3B; HG 20; HG20; HRIHFB2099; Metabotropic GABA B receptor subtype 2; OTTHUMP00000021776; OTTHUMP00000063797; R2 SUBUNIT; BcDNA:GH07312; CG6706; CT20836; D GABA[[B]]R2; D Gaba2; FLJ36928. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細胞膜受體 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 103kDa |
細胞定位 | 細胞膜 |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human GABBR2 around the phosphorylation site of Ser783 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Subunit: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Subcellular Location: ell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Tissue Specificity: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Similarity: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Database links: Entrez Gene: 9568 Human Entrez Gene: 242425 Mouse Omim: 607340 Human SwissProt: O75899 Human SwissProt: Q80T41 Mouse Unigene: 198612 Human Unigene: 101909 Mouse Unigene: 162814 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. g-氨基丁酸(GABA)是哺乳動物中樞神經(jīng)系統(tǒng)中重要的抑制性神經(jīng)遞質(zhì),在體內(nèi)通過作用于離子通道型的GABAA、GABAC受體及代謝型的GABAB受體而發(fā)揮生理功能。 GABAB 受體存在于神經(jīng)元的突觸前及突觸后部位,介導(dǎo)慢的抑制性效應(yīng),在腦內(nèi)參與許多重要的生理活動和病理變化,包括認知損害、癲癇、痙攣及藥物成癮等。 GABAB2在與GABAB1形成二聚體后可激活G蛋白,但它沒有結(jié)合GABA的能力;GABAB2還可增強激動劑與GABAB1的親和力,并且通過與GABAB1形成二聚體結(jié)構(gòu)而屏蔽GABAB1的胞內(nèi)滯留信號。 |
1、抗體溶解方法 | |
2、抗體修復(fù)方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關(guān)于肽鏈的設(shè)計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
| 国产91 丝袜在线播放动 | 人与嘼一区二区三区 | 免费少妇A级毛片人成果冻 免费A片全黄少妇内谢猫叫 | 91成人影库一级A片 国产护士囗交吞精视频 | 亚洲一区二区综合 | 日韩AV一区二区三区 | 成人做爰免费视频免费看 | 国产黄色视频在线观看 | 亚洲精品一区二区三区在线 | 国产精品被狂躁到高潮 | 久久视频在线观看欧美性爱 | 无码精品一区二区三区四区爱奇艺 | 久久久久久国产成人a亚洲精品无码 | 波霸巨大乳一区二区三区 | 人妻丰满熟妇av无码一区二区 | 看免费一级黄色生活录像 | 日美韩蘑菇无码视频 | 91麻豆产精品久久久久久 | 97成人无码精品午夜A片 | www国产色情在线观看 | 中文字幕免费在线观看 | 国产69精品久久久久熟女白洁 | 97国产精品视频人人做人人爱 | 狼人色情乱婬一区二区 | 毛片在线免费观看网站 | 日本熟妇乱妇熟色A片蜜桃 中文字幕乱码人妻二区三区 | 免费A片是视频芊芊视频 | 一区二区免费视频 | 又粗又大又黄的视频 | 一区少妇白洁无码视频 | 性猛交ⅩXXX毛片少妇白浆 | 真实国产乱子伦精品一区二区 | 小向美奈子乳巨码无在线水澄 | 一级BBBBBBBBB裸体| 激情图片激情视频激情小说 | 少妇被c 黄 在线网站AV | 狼人视频国产在线观看 | 亚洲免费视频在线观看免费 | 91嫖妓站街按摩店老熟女 | 久久久久成人精品无码 |