91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
一本一道久久a久久精品蜜桃,亚洲AV成人无码久久精品贰佰网 ,无高清人妻一区二区
Rabbit Anti-phospho-APBB1 (Ser347)/Cy7 Conjugated antibody (bs-5166R-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-5166R-Cy7
英文名稱(chēng) Rabbit Anti-phospho-APBB1 (Ser347)/Cy7 Conjugated antibody
中文名稱(chēng) Cy7標(biāo)記的磷酸化鐵蛋白Fe65抗體
別    名 Adaptor protein FE65a2; Amyloid beta (A4) precursor protein binding family B member 1; Amyloid beta A4 precursor protein binding family B; Amyloid beta A4 precursor protein binding family B member 1; Amyloid beta precursor protein binding family B member 1; APBB 1; APBB1; FE 65; Fe65 protein; MGC 9072; MGC9072; Protein Fe65; RIR; Stat like protein; Fe-65 Protein; APBB1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human APBB1 around the phosphorylation site of Ser347 [SL(p-S)PE]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Function:
Transcription coregulator that can have both coactivatorand corepressor functions. Adapter protein that forms atranscriptionally active complex with the gamma-secretase-derivedamyloid precursor protein (APP) intracellular domain. Plays acentral role in the response to DNA damage by translocating to thenucleus and inducing apoptosis. May act by specifically recognizingand binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph)at double-strand breaks (DSBs), recruiting other pro-apoptosisfactors such as MAPK8/JNK1. Required for histone H4 acetylation atdouble-strand breaks (DSBs). Its ability to specifically bindmodified histones and chromatin modifying enzymes such asKAT5/TIP60, probably explains its trancription activation activity.Function in association with TSHZ3, SET and HDAC factors as atranscriptional repressor, that inhibits the expression of CASP4.Associates with chromatin in a region surrounding the CASP4transcriptional start site(s).

Subunit:
Component of a complex, at least composed of APBB1,RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (withthe intracellular domain of the beta-amyloid precursor protein).Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs thetrancription activation activity. Interacts (via PID domain 1) withKAT5/TIP60. Interacts (via the WW domain) with the proline-richregion of APBB1IP. Interacts with TSHZ1 and TSHZ2 (By similarity).Interacts (via the WW domain) with histone H2AX (whenphosphorylated on 'Tyr-142') and the proline-rich region of ENAH.Interacts with MAPK8. Interacts (via PID domain 1) with TSHZ3 (viahomeobox domain). Interacts with SET. Found in a trimeric complexwith HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 ismediated by TSHZ3. Interacts (via WWW domain) with NEK6. Interacts(via WWW domain) with ABL1.

Subcellular Location:
Cell membrane. Cytoplasm. Nucleus. Cellprojection, growth cone (By similarity). Nucleus speckle.Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity).In normal conditions, it mainly localizes to the cytoplasm, while asmall fraction is tethered to the cell membrane via its interactionwith APP. Following exposure to DNA damaging agents, it is releasedfrom cell membrane and translocates to the nucleus. Nucleartranslocation is under the regulation of APP. Colocalizes withTSHZ3 in the nucleus. Co-localizes with NEK6 at the nuclearspeckles. Phosphorylation at Ser-610 by SGK1 promotes itslocalization to the nucleus

Tissue Specificity:
Highly expressed in brain; strongly reduced inpost-mortem elderly subjects with Alzheimer disease.

Post-translational modifications:
Phosphorylation at Ser-610 by SGK1 promotes its localizationto the nucleus (By similarity). Phosphorylated following nucleartranslocation. Phosphorylation at Tyr-547 by ABL1 enhancestranscriptional activation activity and reduces the affinity forRASD1/DEXRAS1.

Similarity:
Contains 2 PID domains.
Contains 1 WW domain.

Database links:

Entrez Gene: 322 Human

Entrez Gene: 11785 Mouse

Entrez Gene: 29722 Rat

Omim: 602709 Human

SwissProt: O00213 Human

SwissProt: Q9QXJ1 Mouse

SwissProt: P46933 Rat

Unigene: 372840 Human

Unigene: 38469 Mouse

Unigene: 19953 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fe65 蛋白(又稱(chēng)作Amyloid beta A4 precursor protein-binding family B member 1)可能與細(xì)胞內(nèi)的APP結(jié)構(gòu)域結(jié)合調(diào)節(jié)內(nèi)源性的APP。
版權(quán)所有 2004-2026 www.rvdoil.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产又粗又猛又黄又爽无遮挡 | 亚洲高清国产自产AV | 免费看污黄网站 在线观看 污黄网站在线播放观看视频 | 黑人又粗又大一级毛片多人做 | 红桃视频一区二区三区免费 | 欧美成人A片在线观看 | 一级久久久久久片18 | 国产日韩欧美在线观看 | 国产无码在线高清视频 | 精品人妻丝袜久久久久九色 | 西西4444WWW大胆无视频双腿 | 红桃视频一区二区高清码 | 国内精品国产成人国产三级 | 国产亚洲色婷婷久久99精品 | 久久久精品理论A级A片 | 性一交一免一费一视一频 | 人人爽人人爽人人爽 | 看的www在线免费 | 97国产揄拍国产精品 | 亚洲裸体漫画在线观看 | 日韩性爱视频免费网站 | 色欲av在线免费观看 | 中日韩精品A片日本有码 | 国产一级a毛一级a看免费视频乱 | 国产精品丰满人妻G奶 | 精品国产免费久久久久久桃子图片 | 中文字幕手机在线观看 | 亚洲中文无码视频 | 毛片在线免费观看视频 | 老师白洁在线播放麻豆 | 国产激情久久久久久一级A片老师 | 亚洲色图无码在线观看 | 成人做爰www免费网站 | 亚洲精品无码久久久久苍井空国产一 | 四川BBB搡BBB搡多人孕妇 | 久久高清欧美国人妻精品 | 亚洲精品字幕在线观看 | 午夜福利1000集福利视频 | 亚洲激情视频在线观看 | 成人精品无码秘 入口网址 91丝袜人妻高跟精品69 | 国产丨熟女丨国产熟女视频 |