| 產(chǎn)品編號 | bs-1331R-BF488 |
| 英文名稱 | Rabbit Anti-SFRP4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的子宮內(nèi)膜抗體 |
| 別 名 | sFRP-4; Secreted frizzled-related protein 4; Frizzled protein, human endometrium; FrpHE; SFRP4; SFRP4_MOUSE; SFRP4_HUMAN; FRPHE. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 干細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human sFRP-4 C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. [SUBCELLULAR LOCATION] Secreted. Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Belongs to the secreted frizzled-related protein (sFRP) family. Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung. Similarity: Belongs to the secreted frizzled-related protein (sFRP) family. Contains 1 FZ (frizzled) domain. Contains 1 NTR domain. Database links: Entrez Gene: 6424 Human Entrez Gene: 20379 Mouse Omim: 606570 Human SwissProt: Q6FHJ7 Human SwissProt: Q9Z1N6 Mouse Unigene: 658169 Human Unigene: 42095 Mouse Unigene: 10788 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 抗子宮內(nèi)膜抗體屬于自身抗體，在正常育齡婦女中也可以檢測到，但在不孕癥人群中，特別是患有子宮內(nèi)膜異位癥的婦女中更多見。 正常機(jī)體具有自身免疫調(diào)節(jié)功能，產(chǎn)生極弱的自身抗體，幫助清除體內(nèi)衰老變性的自身成分，但由于某種原因?qū)е旅庖呦到y(tǒng)對自身組織產(chǎn)生過度免疫應(yīng)答，則會發(fā)生過強(qiáng)的一系列免疫反應(yīng)，致使所侵及的組織免疫活性細(xì)胞增多，免疫復(fù)合物沉積，而導(dǎo)致功能改變。當(dāng)這種抗子宮內(nèi)膜抗體由于反復(fù)刺激而大量產(chǎn)生達(dá)到一定的含量時，可與自身的子宮內(nèi)膜組織發(fā)生抗原抗體結(jié)合反應(yīng)，并激活免疫系統(tǒng)引起損傷性效應(yīng)，造成子宮內(nèi)膜組織細(xì)胞生化代謝及生理功能的損害，干擾和妨礙精卵結(jié)合，受精卵的著床和胚囊的發(fā)育而導(dǎo)致不孕或流產(chǎn)。 |
