| 產(chǎn)品編號 | bs-0772R-BF488 |
| 英文名稱 | Rabbit Anti-phospho-FSCN1(Ser39)/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的磷酸化纖維束蛋白同源物1抗體 |
| 別 名 | Fascin (phospho S39); Fascin (phospho S39); 55 kDa actin bundling protein; Actin bundling protein; FAN 1; FAN1; Fascin 1; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like protein; SNL; Strongylocentrotus purpuratus. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, ) |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human FSCN1 around the phosphorylation site of Ser39 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells. Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Subcellular Location: Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. Similarity: Belongs to the fascin family. Database links: Entrez Gene: 6624 Human Entrez Gene: 14086 Mouse Omim: 602689 Human SwissProt: Q16658 Human SwissProt: Q61553 Mouse Unigene: 118400 Human Unigene: 289707 Mouse Unigene: 199526 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肌動蛋白集束蛋白/圓線蟲紫癜抗體。 FSCN1為細(xì)胞骨架肌動蛋白的一種，該蛋白有蛋白結(jié)合,橋連、肌動蛋白絲結(jié)合的功能。 主要參與細(xì)胞增殖、肌動蛋白細(xì)胞骨架組織和生物發(fā)生、肌動蛋白絲束形成。< |
