| 產(chǎn)品編號 | bs-1196R-BF488 |
| 英文名稱 | Rabbit Anti-Proteinase-activated receptor 4/PAR4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的蛋白酶活化受體4抗體 |
| 別 名 | F2RL3; F2R Like Thrombin/Trypsin Receptor 3; Coagulation Factor II (Thrombin) Receptor-Like 3; Thrombin Receptor-Like 3; PAR-4; PAR4; Coagulation Factor II Receptor-Like 3; Proteinase-Activated Receptor-4; Proteinase-Activated Receptor 4; Protease-Activated Receptor-4; PAR4_HUMAN; |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Proteinase-activated receptor 4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008] Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links:
Entrez Gene: 9002 Human
Omim: 602779 Human
SwissProt: Q96RI0 Human
Unigene: 137574 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 蛋白酶活化受體-4是蛋白酶活化受體PARs (protease-activated receptors , PARs)的成員之一，PAR4在激活、滅活、脫敏、復(fù)敏、及其與信號轉(zhuǎn)導(dǎo)途徑的關(guān)系,尤其是與疾病的關(guān)系正倍受關(guān)注。 PAR4具有廣泛的生物學(xué)效應(yīng),最終影響細(xì)胞的形態(tài)的改變、分泌蛋白和整合蛋白的活化、代謝反應(yīng)、轉(zhuǎn)錄過程和細(xì)胞運動，由此參與細(xì)胞的信號轉(zhuǎn)導(dǎo)作用。 |
