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Rabbit Anti-Cyclin L/BF555 Conjugated antibody (bs-7888R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7888R-BF555
英文名稱 Rabbit Anti-Cyclin L/BF555 Conjugated antibody
中文名稱 BF555標記的周期素L抗體
別    名 Ania 6a; BM 001; CCNL 1; CCNL1; CCNL1_HUMAN; Cyclin L ania 6a; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞周期蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, Chimpanzee, mpanzee)
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin L/CCNL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Tissue specificity;Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).

Function:
Transcriptional regulator which participates inregulating the pre-mRNA splicing process. Seems to be involved inthe regulation of RNA polymerase II (pol II). Functions inassociation with cyclin-dependent kinases (CDKs) and has a role inthe second step of splicing. May be a candidate proto-oncogene inhead and neck squamous cell carcinomas (HNSCC). Inhibited by theCDK-specific inhibitor p21.

Subunit:
Interacts with POLR2A via its hyperphosphorylatedC-terminal domain (CTD) (By similarity). Interacts with CDK11A,CDK11B, CDK12, CDK13 and SFRS2.

Subcellular Location:
Nucleus speckle (By similarity). Note=Morespecifically found in nuclear intrachromatin granules clusters(IGC), also called nuclear speckles, which are storage compartmentsfor nuclear proteins involved in mRNA processing (By similarity).

Tissue Specificity:
Ubiquitous with higher level in thymus.Overexpression in primary tumors of head and neck squamous cellcarcinomas (HNSCC).

Similarity:
Belongs to the cyclin family. Cyclin L subfamily.

Database links:
UniProtKB/Swiss-Prot: Q9UK58.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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