91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
少妇搡BBBB搡BBB搡毛片,国产精品一级毛片A片骨灰盒,特级婬片A片AAA毛片咕噜咕噜
Rabbit Anti-Cyclin E1/Gold Conjugated antibody (bs-0573R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0573R-Gold
英文名稱 Rabbit Anti-Cyclin E1/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的周期素E抗體
別    名 CCNE 1; CCNE; CCNE1; Cyclin E1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat Cyclin E
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.

Subunit:
Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Post-translational modifications:
Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the cyclin family. Cyclin E subfamily.

Database links:

Entrez Gene: 898 Human

Entrez Gene: 12447 Mouse

Entrez Gene: 25729 Rat

Omim: 123837 Human

SwissProt: P24864 Human

SwissProt: Q61457 Mouse

SwissProt: P39949 Rat

Unigene: 244723 Human

Unigene: 16110 Mouse

Unigene: 15455 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


細(xì)胞周期素E是調(diào)控細(xì)胞G-1→S期轉(zhuǎn)變的關(guān)鍵因素。由于在多種腫瘤中的不適當(dāng)表達(dá),細(xì)胞周期素E現(xiàn)在已明確為原癌基因。
版權(quán)所有 2004-2026 www.rvdoil.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
波多野结衣在线观看一区二区三区 | 色情网一区二区三区四区无码视频 | 日韩人妻无码一区二区 | 台湾佬中文91色欲视频合集 | 苍井空亚洲精品AA片在线播放 | 国产红桃一区二区 | 亚洲中文字幕在线观看视频 | chinese熟女老女人hd视频 | 91丨国产丨白浆秘 喷淫网站 | 丝袜 美腿 性爱 电影 麻豆 | 日韩无码性爱视频 | 亚洲色婷婷国产精品杨思敏 | 成在线人永久免费视频播放 | 久久无码人妻一区二区三区午夜免费 | 人妻丰满熟妇一区二区三区 | 印度强奸av手机天堂网 | 国产无人区码熟妇毛片多 | 国产一区三区王色视频 | JUKD575中文字幕人妻 | 日韩精品无码1000 | 国产毛片精品一区二区色欲黄A片 | 国产看真人毛片爱做A片 | 国产精品成人久久久久 | 好大好爽一区二区蜜桃 | 国产精品农村妇女AAAA | 扒开腿挺进肉嫩小泬喷水网站在线观看 | free性满足HD国产 | 亚洲精品久久久久久久久久久久久 | 成人女同 AV在线观看 | 波多野结衣高清无码 | 成人AV一区二区三区 | 波多野结衣乳喷高潮五分高潮 | 国产精品高潮呻吟久久 | 蜜桃视频一区二区三区 | 欧美熟妇BBB搡BBB | 国产精品人妻无码久久久福利彩票 | 波多野结衣乳巨码无免费 | 亚洲一区二区三区在线观 | 拍真实国产伦偷精品 | 精品国产免费一区二区三区香蕉 | 一级黄色超级超级片中国 |