產(chǎn)品編號(hào) | bs-3393R-BF488 |
英文名稱(chēng) | Rabbit Anti-Phospho-SIRT1(Ser47)/BF488 Conjugated antibody |
中文名稱(chēng) | BF488標(biāo)記的磷酸化沉默調(diào)節(jié)蛋白1抗體 |
別 名 | 75SirT1; BA57G10.4; hSIR2; hSIRT1; NAD dependent deacetylase SIRT1; NAD dependent deacetylase sirtuin 1; NAD dependent deacetylase sirtuin 2; Silent mating type information regulation 2; OTTHUMP00000198111; OTTHUMP00000198112; SIR2 like 1; SIR2 like protein 1; SIR2-like protein 1; Regulatory protein SIR2 homolog 1; SIR1_HUMAN; SIR2ALPHA; SIR2alpha protein; SIR2L1; SIR2L2; SIRT 1; SIRT-1; Sirt1; SIRT1 Sir2 like proteins (siruitins) type 1; SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); SirtT1 75 kDa fragment; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1; sirtuin; Sirtuin type 1; Sirtuin type 2. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
產(chǎn)品類(lèi)型 | 磷酸化抗體 |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 微生物學(xué) 新陳代謝 表觀遺傳學(xué) |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Human, Rat, (predicted: Mouse, Dog, Pig, Rabbit, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 58/81kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human SirT1 around the phosphorylation site of Ser47 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. Function: SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. Subunit: Found in a complex with PCAF and MYOD1 (By similarity). Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with HES1, HEY2 and PML. Interacts with RPS19BP1/AROS. Interacts with KIAA1967/DBC1 (via N-terminus); the interaction disrupts the interaction between SIRT1 and p53/TP53. Interacts with SETD7; the interaction induces the dissociation of SIRT1 from p53/TP53 and increases p53/TP53 activity. Interacts with MYCN, NR1I2, CREBZF, TSC2, TLE1, FOS, JUN, NR0B2, PPARG, NCOR, IRS1, IRS2 and NMNAT1. Interacts with HNF1A; the interaction occurs under nutrient restriction. Interacts with SUZ12; the interaction mediates the association with the PRC4 histone methylation complex which is specific as an association with PCR2 and PCR3 complex variants is not found. Interacts with HIV-1 tat. Subcellular Location: Nucleus, PML body. Cytoplasm. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm. SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion. Tissue Specificity: Widely expressed. Post-translational modifications: Methylated on multiple lysine residues; methylation is enhanced after DNA damage and is dispensable for deacetylase activity toward p53/TP53. Phosphorylated. Phosphorylated by STK4/MST1, resulting in inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by MAPK8/JNK1 at Ser-27, Ser-47, and Thr-530 leads to increased nuclear localization and enzymatic activity. Phosphorylation at Thr-530 by DYRK1A and DYRK3 acivates deacetylase activity and promotes cell survival. Phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) at Ser-47 inhibits deacetylation activity. Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B p65/RELA deacetylation activity (By similarity). Phosphorylation at Ser-27 implicating MAPK9 is linked to protein stability. There is some ambiguity for some phosphosites: Ser-159/Ser-162 and Thr-544/Ser-545. Proteolytically cleaved by cathepsin B upon TNF-alpha treatment to yield catalytic inactive but stable SirtT1 75 kDa fragment (75SirT1). S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent protein deacetylase activity (By similarity). Similarity: Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain. Database links: Entrez Gene: 23411 Human Entrez Gene: 93759 Mouse Omim: 604479 Human SwissProt: Q96EB6 Human SwissProt: Q923E4 Mouse Unigene: 369779 Human Unigene: 351459 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 在Sirtuin蛋白家族中,sirtuin 1參與多種新陳代謝活動(dòng),包括DNA的自我保護(hù)和修復(fù),抑制脂質(zhì)過(guò)氧化積累,抑制其他細(xì)胞凋亡相關(guān)基因的表達(dá)以及和細(xì)胞壽命相關(guān)的活動(dòng)。限制攝入的熱量可以加強(qiáng)SIRT1的表達(dá),從而延長(zhǎng)了壽命。 |
| 午夜福利视频1000 | 国产乱子伦精品视频潮 | 裸体美女嫩BBB观赏 免费黄色视频在线观看 | bLacK欧美黑鸡巴操逼 | 欧美农村妇女精品一区二区 | 国产做爰又粗又大又爽小妖精 | 国产无遮挡A片又黄又爽小直播 | 国语对白乱妇激情视频 | 国产精品人成A片一区二区 国产亚洲东北熟女高潮叫床 | 潮喷 合集 喷水 mp4 | 黄色免费一级少妇喷水a片 色婷婷五月色综合AⅤ色欲 | 国产精品久久久久无码AV | 特一级一性一交一视一频 | 成人午夜做爰高潮片免费吸气 | 911亚洲精品无码成人A片在线 | 亚洲AV日韩精品国产成人网站 | 午夜成人理论片A片AAA软件 | 91亚洲精品久久久蜜桃 借种 | 免费在线观看视频网站黄色的话说 | 又大又粗弄得我好舒服 | 欧美性爱XXX黑人性爽 | 强制高潮(H)调教视频 | 精品99视频免费在线观看 | 好男人一区二区三区在线观看 | 亚洲国产精久久久久久久 | 叉女人动态图片120秒 | 榆林万人坑一级黄色毛片 | 看一级全裸黄色视频在线观看 | 91在线无码精品秘 人口传媒 | 红桃视频在线观看免费一区二区三区 | 久久精品人妻一区二区三区 | 国产精品成人一区二区无码久久 | 波多野结衣在线观看一区 | 手机在线观看av | 人妻中出丝袜 井川ゆい | 西西444WWW无码视频软件 | 又大jizz又粗又硬又爽又黄毛片视频 | 在线观看黄色小视频 | 无码久久人体做爰大胆 | 中文一区二区高清无码 |