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Rabbit Anti-Sema6A/Gold Conjugated antibody (bs-2701R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2701R-Gold
英文名稱 Rabbit Anti-Sema6A/Gold Conjugated antibody
中文名稱 膠體金標記的Sema6A抗體
別    名 semaphorin 6A; Sema Q; Sema VIA; SEMA6A-1; Semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; HT018; SEM6A_HUMAN; SEMA; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; SEMA6A 1; Sema6a; SEMA6A1; Semaphorin 6A 1; Semaphorin Q; Semaphorin VIA; Semaphorin-6A; Semaphorin-6A-1; SEMAQ; VIA.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  神經(jīng)生物學  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 111kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sema6A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein.

Function:
Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.

Subunit:
Active as a homodimer or oligomer. Interacts with EVL.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Database links:

Entrez Gene: 516019 Cow

Entrez Gene: 57556 Human

Entrez Gene: 20358 Mouse

Omim: 605885 Human

SwissProt: Q9H2E6 Human

SwissProt: O35464 Mouse

Unigene: 156967 Human

Unigene: 40909 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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