產(chǎn)品編號(hào) | bs-2677R-Cy7 |
英文名稱 | Rabbit Anti-LRP1/Cy7 Conjugated antibody |
中文名稱 | Cy7標(biāo)記的低密度脂蛋白受體相關(guān)蛋白1抗體 |
別 名 | A2MR; Alpha 2 macroglobulin receptor; alpha 2MR; APOER; Apolipoprotein E receptor; APR; CD 91; CD91; CD91 antigen; Low density lipoprotein receptor related protein 1; Low density lipoprotein related protein 1; LRP 1; LRP 515; LRP 85; LRP; LRP ICD; LRP1; LRP1 protein; LRP515. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 合成與降解 Alzheimer's |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Horse, ) |
產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 500kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human CD91 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus. Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Subcellular Location: Cell membrane. Membrane, coated pit and Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Tissue Specificity: Most abundant in liver, brain and lung. Post-translational modifications: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. Similarity: Belongs to the LDLR family. Contains 22 EGF-like domains. Contains 31 LDL-receptor class A domains. Contains 34 LDL-receptor class B repeats. Database links: Entrez Gene: 4035 Human Entrez Gene: 16971 Mouse Entrez Gene: 100009547 Rabbit Omim: 107770 Human SwissProt: Q07954 Human SwissProt: Q91ZX7 Mouse Unigene: 162757 Human Unigene: 271854 Mouse Unigene: 22436 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产无套精品一区二区三区 | 精品人妻无码一区二区性色 | 中文字幕乱码视频播放 | 成人h动漫精品一区二区 | 久久人人国精品蜜桃 | 国产无 码免费观看少萝 | 国产一区波多野结衣 | 免费观看婬片A片AAA毛片蜜唇 | 波多野结衣久久久无码 | 好吊视频一区二区三区 | 人一禽一性一交乱一区 | 强行糟蹋人妻HD中文 | 可以直接看的黄色视频 | 免费在线观看黄色视频网站 | 天天婬欲婬香婬色婬动态 | 啊轻点灬太粗嗯太深A片 | 久久久国产精品红桃视频 | 黄色视频AAA级毛片 欧美必出精品在线观看 | 国产无套内射普通话对白 | XXXX性XXXXu公交车 | 91精品国产高清一区二区三区蜜臀 | 绿帽3p视频一区二区三区 | 全免费A级毛片免费看黄瓜视频 | 亚a洲成人无码久久久 | 黄色视频链接在线观看 | 91丨人妻丨大屁股 | 精品乱子伦一区二区三区 | 国产一级婬乱片AV片AAA毛片 | 免费看人与拘做受A片 | 国产精品久久久久久无码欧美内衣 | 亚洲无码视频在线 | A片毛一区二区三区农村 | 又大又粗又爽18禁免费看 | 成人做爰A片免费看视频 | 久久久噜久噜久久综合 | 好吊操视频这里有精品 | 91人妻久久久精品中文字幕瑜伽 | 真实的国产乱XXXX在线 | 中文字幕人妻一区二区三区视频 | 亚洲 国产 另类视频 |