產(chǎn)品編號(hào) | bs-11677R-BF488 |
英文名稱 | Rabbit Anti-UCHL1+3/BF488 Conjugated antibody |
中文名稱 | BF488標(biāo)記的泛素硫酯酶L1+3抗體 |
別 名 | Epididymis luminal protein 117; Epididymis secretory protein Li 53; HEL 117; HEL S 53; NDGOA; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; Park 5; PARK5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase; Ubiquitin C terminal hydrolase L1; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH-L1; UCHL1; UCHL1_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 泛素 Alzheimer's |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 25kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human UCHL1+3 (141-223aa) |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The two ubiquitin C-terminal hydrolase (UCH) enzymes, UCHL1 and UCHL3, deubiquitinate ubiquitin-protein conjugates and control the cellular balance of ubiquitin. UCHL1 and UCHL3 are both small proteins of ~220 amino acids that share more than 40% amino acid sequence identity. UCHL3 is universally expressed in all tissues, while UCHL1 is expressed exclusively in neuronal tissue, testis and ovary. The activity of UCHL3 is more than 200 fold higher than UCHL1 when a fluorogenic ubiquitin substrate is used. UCHL1 associates with monoubiquitin and UCHL3 binds to Nedd8, ubiquitin-like protein. UCHL1 and UCHL3 play a role in the regulation of neuronal development and spermatogenesis. UCHL1 is involved in the pathogenesis of Parkinson’s disease (PD) and Alzheimer’s disease (AD). Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Subunit: Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5. Subcellular Location: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain. Tissue Specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Post-translational modifications: O-glycosylated DISEASE: Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Similarity: Belongs to the peptidase C12 family. Database links: Entrez Gene: 7345 Human Entrez Gene: 22223 Mouse Entrez Gene: 101117250 Sheep Omim: 191342 Human SwissProt: P09936 Human SwissProt: Q9R0P9 Mouse Unigene: 518731 Human Unigene: 29807 Mouse Unigene: 107213 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 后入内射欧美99二区视频 | 成人免费A片在线看 | 蜜芽亚洲丝袜一区 | 国产一级片一区二区 | 妞干网万部免费观看日韩精品 | 一牛影视一区二区三区 | 人人澡人人添人人爽一区二区 | 日韩人妻无码精品一区二区 | 少妇性色婬片AAA直播 | 亚洲欧美一区二区三区国产精品 | 国产精品亚洲欧美日韩久久制服诱 | 蜜桃秘 av无码一区二区三区 | 国产人妻人伦精品久久久电影 | 又粗又大农村妇女A片 | 丰满人妻被猛烈进入中文字幕 | 手机大片福利社亚洲天堂 | 国产精品久久久久久搜索 | 南京搡BBBB搡BBBB| 亚洲无码免费在线观看 | 奶大灬舒服灬又爽灬高潮 | 777琪琪午夜理论片在线观看 | www.777色情网免费视频 | 爱咲れいら无码一区二区 | 成人性做爰AAA片免费 | 精品丰满人妻少妇Av无码 | 99久久久无码国产精品性青椒 | 18禁免费久久久久久久 | 亚洲精品无线乱码一区 | www.狠狠色婷婷综合蜜桃 | 国产无套内射普通话对白 | 国产精品18久久久久久首页狼 | 国产午夜视频在线看 | 成人A片产无码免费视频奶头红杏 | 色狠狠色噜噜AV天堂五区消防 | 国偷自拍AV一区二区三区在线 | 第1一40章免费阅读 国产又粗又长又白又大 | 亚洲中文字幕在线中出 | ZZJJ国产精品一区二区 | 国产伦子伦视频免费播放 | 少妇BBBB搡BBBB搡BBBB |