產(chǎn)品編號(hào) | bs-9931R-BF594 |
英文名稱 | Rabbit Anti-KCNJ5/BF594 Conjugated antibody |
中文名稱 | BF594標(biāo)記的G蛋白激活內(nèi)向鉀通道5抗體 |
別 名 | inwardly rectifying subfamily J member 5; Cardiac ATP sensitive potassium channel; Cardiac inward rectifier; CIR; G protein activated inward rectifier potassium channel 4; G protein-activated inward rectifier potassium channel 4; GIRK 4; GIRK-4; GIRK4; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; Inward rectifier K+ channel KIR3.4; IRK-4; IRK5_HUMAN; KATP 1; KATP-1; KATP1; KCNJ 5; Kcnj5; KIR 3.4; KIR3.4; Potassium channel; Potassium channel inwardly rectifying subfamily J member 5; Potassium inwardly rectifying channel J5; Potassium inwardly rectifying channel subfamily J member 5. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 腫瘤 心血管 神經(jīng)生物學(xué) 通道蛋白 G蛋白信號(hào) |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 48kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human KCNJ5 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]. Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Subunit: May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Islets, exocrine pancreas and heart. DISEASE: Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Defects in KCNJ5 are the cause of familial hyperaldosteronism type 3 (FH3) [MIM:613677]. A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. Like patients with familial hyperaldosteronism type 1 (glucocorticoid-remediable aldosteronism), patients with FH3 present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. However, hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension. Note=Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas and can be responsible for aldosteronism associated with cell autonomous proliferation. These are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. KCNJ5 mutations produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily. Database links: Entrez Gene: 3762 Human Entrez Gene: 16521 Mouse Omim: 600734 Human SwissProt: P48544 Human SwissProt: P48545 Mouse Unigene: 632109 Human Unigene: 69472 Mouse Unigene: 10047 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Involvement in disease; Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13). It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. |
| 国产伦子伦一级A片免费看小说 | 成人做爰高潮A片免费视频 真实的国产乱ⅩXXX88 | 国产在线播放黄色影院 | 南京搡BBBB搡BBBB | 欧美性爱XXXX黑人XYX性爽 | 十八禁黄网站禁片 | 色婷婷精品久久二区二区6 在线观看亚洲黄色视频网站 | 性受 XXXX黑人XYX性爽 | 囯产精品久久久久久久久免费蜜桃视频 | 国产一级a毛一级a | 无码人妻一区二区三区免费京洛会 | 日本无码高清在线视频 | 一级毛片久久久久久久女人18 | 国产一级a毛一级a毛观看视频网站 | 搡老女人老妇女aaa一区麻豆 | 无码视频在线免费观看 | 婷婷五月婷婷一区二区三区久久久 | 美女隐私黄片无需下载纯欧美少妇 | 18一20岁一级毛片 | 国产一级婬片A片AAA蜜臂 | 有码无码国产在线播放 | 中文字幕一级A片免费看 | 91精国产品一区二区 | 9l人人澡人人妻人人精品 | 精品国产一区二区国模嫣然 | 国语对白做受 欧美 | 成人国产精品秘 入麻豆 | 爽灬爽灬爽灬毛及A片 | 日本淫乱无码一区二区 | 人妻人妻在线精品片98 | 91在线观看视频免费 | 丰满岳乱妇一区二区 | 91亚洲精品久久久久蜜桃 | 91ThePorn入口| 免费在线观看午夜福利 | 久久中国国产Av秘 人妻 | 西西444WWW无码视频软件 | 午夜理理伦电影A片无码蜜桃av | 男女啊啊啊啊爱爱爱爱 | 裸体美女18禁免费看久久 |