產(chǎn)品編號 | bs-1832R-BF488 |
英文名稱 | Rabbit Anti-PPARGC1A/BF488 Conjugated antibody |
中文名稱 | BF488標(biāo)記的過氧化物酶體增殖物激活受體γ輔激活子1α抗體 |
別 名 | LEM6; PGC-1 Alpha; PGC1 Alpha; Ligand effect modulator 6; Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; Peroxisome proliferative activated receptor, gamma, coactivator 1 ; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC1; PGC1(alpha); PGC1A; PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPARGC 1 alpha; PPARGC1A. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 88kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human PGC-1 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene. Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Subunit: Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with PRDM16. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1. Subcellular Location: Nucleus. Tissue Specificity: Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. Post-translational modifications: hosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. Similarity: Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 422815 Chicken Entrez Gene: 10891 Human Entrez Gene: 19017 Mouse Omim: 604517 Human SwissProt: Q9UBK2 Human SwissProt: O70343 Mouse Unigene: 527078 Human Unigene: 259072 Mouse Unigene: 19172 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PGC-1α是一個新發(fā)現(xiàn)的轉(zhuǎn)錄激活因子,起到高游離脂肪酸刺激胰島α細(xì)胞分泌的重要調(diào)控作用。 |
| 国产看真人毛片爱做A片 | 一级毛片真人免费视频 | 国产裸体美女永久免费视频 | 91性高潮久久久久久久 | 亚洲AV无码专区一级淫片毛片 | 少妇性私人影院A片99A片 | 少妇的BBBB爽爽爽自慰 | 国产传媒啊啊啊视频 | 少妇婬荡视频在线播放 | 久久久久久久极品内射 | 人妻野战在线一区三区 | 激情图片激情视频激情小说 | 91在线无码精品秘 蜜桃按摩 | 特黄做受又粗又大又硬老头视频 | 少妞躁BBB少妞躁BBBB | 日本中文字幕在线播放 | 欧美毛片又粗又长又 | 国产成人久久精品亚洲 | 无码人妻丰满少妇熟妇区五十路 | 久久AV红桃秘 一区二区 | 99久久婷婷国产一区二区三区 | 国产成人AV一区二区三区 | 91无码人妻精品一区二区三区四 | 我丰满的岳 久久国产 | 国产精品毛片毛豆传媒 | Av一小次郎,三级片 黄色无码视频免费观看 | 狂暴强伦轩一区二区三区四区 | 欧美一级VA免费观看 | 夜精品A片一区二区无码妖精视频 | 水多多成人A片在线观看播放 | 激情图片激情视频激情小说 | 中国大学生老师性服务黄色片一区二区 | 97精品超碰一区二区三区 | 日本熟妇乱妇熟色A片蜜桃 中文字幕乱码人妻二区三区 | 国产91九色足控脚交在线播放 | 久久精品人妻一区二区三区 | 国产资源在线播放 | 日本不卡视频在线观看 | 少妇被躁到高潮无码a片游戏 | 成人 高潮片免费视频 |