| 產(chǎn)品編號(hào) | bs-1559R-BF488 |
| 英文名稱 | Rabbit Anti-GLP-1R/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的胰高血糖素樣肽-1受體/GLP-1受體抗體 |
| 別 名 | Glucagon like peptide-1 receptor; GLP 1 R; GLP 1 receptor; GLP 1R; Glp1r; GLP; glp1r; Glucagon like peptide 1 receptor; RATGL1RCP; Glip;MGC138331; GLP-1-R; GLP1R_HUMAN; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; Precursor. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 生長因子和激素 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLP-1R C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: GLP1R is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.It has been suggested that this protein influences the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. GLP1R is believed to be expressed in human pancreas,lung, brain, stomach, kidney and heart. ESTs have been isolated from skin and kidney libraries. Function: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subunit: May form homodimers and heterodimers with GIPR. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. Similarity: Belongs to the G-protein coupled receptor 2 family. Database links: Entrez Gene: 2740 Human Entrez Gene: 14652 Mouse Omim: 138032 Human SwissProt: P43220 Human SwissProt: O35659 Mouse Unigene: 389103 Human Unigene: 390969 Mouse Unigene: 11408 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GLP-1R是GLP-1在體內(nèi)作用的主要靶點(diǎn),它是一個(gè)7次跨膜的G蛋白偶聯(lián)受體,以cAMP為主要第二信使。GLP-1與GLP-1R結(jié)合過程是一個(gè)兩結(jié)構(gòu)域相互作用的過程,都與胰島素分泌和糖代謝調(diào)節(jié)密切相關(guān)。 |
