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Rabbit Anti-Cathepsin L/Biotin Conjugated antibody (bs-1508R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1508R-Bio
英文名稱 Rabbit Anti-Cathepsin L/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的組織蛋白酶L抗體
別    名 Cathepsin L heavy chain; Cathepsin L light chain; CathepsinL; CATL; CTSL; CTSL protein; DKFZp686A18159; FLJ31037; Major excreted protein; MEP; cath-L; CL; CATL1_HUMAN; CathepsinL1; Cathepsin L1,Cathepsin-L1; CTSL 1; CTSL-1,CTS L1,CTS-L1.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 激酶和磷酸酶  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19/30/37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human cathepsin L1 proprotein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.

Function:
Important for the overall degradation of proteins in lysosomes.

Subunit:
Dimer of a heavy and a light chain linked by disulfide bonds.

Subcellular Location:
Lysosome.

Similarity:
Belongs to the peptidase C1 family.

Database links:

Entrez Gene: 1514 Human

Entrez Gene: 13039 Mouse

Entrez Gene: 25697 Rat

Omim: 116880 Human

SwissProt: P07711 Human

SwissProt: P06797 Mouse

SwissProt: P07154 Rat

Unigene: 726015 Human

Unigene: 930 Mouse

Unigene: 1294 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
組織蛋白酶L(cathepsin L CL)屬于木瓜蛋白酶家族中的半胱氨酸蛋白水解酶,以酶原的形式貯存于溶酶體中. 參與許多特殊的生理過程,如激素原的激活、抗原呈遞、組織器官的發(fā)育等。
在病理狀態(tài)下,因各種原因所致的細胞損傷(如病原微生物、炎癥因子、氧化應(yīng)激等)可降解細胞成分或細胞間質(zhì)基質(zhì)成分,包括層粘素、IV型膠原纖維及纖維連接素等,與人類許多疾病如腫瘤的浸潤與轉(zhuǎn)移、關(guān)節(jié)炎、骨質(zhì)疏松、阿爾茨海姆病、多發(fā)性硬化癥及其他慢性炎癥性疾病有關(guān).
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