| 產(chǎn)品編號(hào) | bs-1442R-Gold |
| 英文名稱(chēng) | Rabbit Anti-Arfaptin 2/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標(biāo)記的ADP核糖基化因子結(jié)合蛋白2抗體 |
| 別 名 | ARFIP2; arfaptin 2; ADP-ribosylation factor interacting protein 2; Partner of RAC1; POR1; ARFP2_HUMAN . |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Arfaptin 2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes. Function: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling. Subunit: Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level. Similarity: Contains 1 AH domain. Database links: Entrez Gene: 23647 Human Entrez Gene: 76932 Mouse Omim: 601638 Human SwissProt: P53365 Human SwissProt: Q8K221 Mouse Unigene: 595146 Human Unigene: 75139 Human Unigene: 41637 Mouse Unigene: 73878 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 交換和轉(zhuǎn)運(yùn)（Trafficking and Transport） |
