91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91在线无码精品秘 入口不卡,性猛交 欧美
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-IRF-1/RBITC Conjugated antibody (bs-1404R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1404R-RBITC
英文名稱 Rabbit Anti-IRF-1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的干擾素調(diào)節(jié)因子1抗體
別    名 interferon regulatory factor 1; IRF 1; IRF1; IRF-1; MAR1; IRF1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRF-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression.

Function:
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.

Subunit:
Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300.

Subcellular Location:
Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1.

Post-translational modifications:
Phosphorylated by CK2 and this positively regulates its activity.
Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.
Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.

DISEASE:
Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Database links:

Entrez Gene: 3659 Human

Omim: 147575 Human

SwissProt: P10914 Human

Unigene: 436061 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉(zhuǎn)錄調(diào)節(jié)因子(Transcriptin Regulators)
干擾素調(diào)節(jié)因子(IRF-1)可刺激IFN-gamma的生成,IRF-1 是T細胞和B細胞分化和成熟的重要調(diào)節(jié)因子。
干擾素調(diào)節(jié)因子家族是一大類對干擾素起調(diào)控作用的轉(zhuǎn)錄因子的統(tǒng)稱。 一般認為干擾素調(diào)節(jié)因子(IRF)通過調(diào)節(jié)干擾素的表達而行使其抗病毒、應(yīng)激、免疫調(diào)節(jié)功能。近年來,研究人員發(fā)現(xiàn)IRF在細胞凋亡、細胞周期、細胞分化、腫瘤發(fā)生中也起著重要的調(diào)節(jié)作用。
版權(quán)所有 2004-2026 www.rvdoil.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
成人喂奶在线偷拍 | 中文字幕第一页亚洲网站 | 国产成人AV一区二区三区 | 91人妻人人爽精品破 | 国产裸体美女免费无遮挡 | 免费A片久久久久久16色 | 成人做爰黄AA片啪啪声 | 少妇做爰A片免费看淑女出墙 | 91久久无码一区人妻A片蜜桃 | 韩国免费一级a一片在线播放 | 少妇又色又紧又黄又刺激 | 精品一性一色一乱农村 | 中文字幕一二三区 | 日韩嫩BBBBBBBBB免费 | 一级婬片A片试看45分钟 | 国产做受18~20岁A片 | 成人国产精品秘 鲁鲁3D | 脫衣舞一区二区三区 | 免费无码人婬片AAAA公交车 | 无码精品人在线观看 | 国产在线观看精品一区 | 一级卖婬片A片AAAA鲁大师 | 国产又粗又黄又爽又硬的蘑菇 | 久热这里只有精品伦理片 | 91丨九色丨偷拍老熟女 | 人人澡人人爱人人摸 | 国产熟女真实乱精品视频 | 一线大片久久久久久久久久久久久久久18 | 九级久久久全国免费视频 | 特黄无码人妻丰满少妇啪啪 | 少妇高潮喷水尖叫抽搐 | 人人妻人人操人人操 | 国产农村伊人AV色小U女 | 欧美一级片在线观看 | 人妻无码久久一区二区免费麻豆 | 成人网站久久久久久久 | 亚洲嫩模视频免费观看 | 另类老妇性BBwBBw | 成人午夜免费福利视频 | 日本无码一区二区蜜桃小说 | 亚洲中文久久精品无码比基尼 |