| 產(chǎn)品編號 | bs-0895R-AP |
| 英文名稱 | Rabbit Anti-FSH receptor/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的促卵泡刺激素受體抗體 |
| 別 名 | Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSHRO; LGR1; ODG1; Follicle-stimulating hormone receptor; FSH-R; FSH R; Fshr; FSHR_HUMAN; MGC141667; MGC141668; ovarian dysgenesis 1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FSHR 225-270aa |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Function: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Subunit: Interacts with ARRB2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Sertoli cells and ovarian granulosa cells. DISEASE: Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. Database links: Entrez Gene: 2492 Human Entrez Gene: 14309 Mouse Entrez Gene: 443299 Sheep Omim: 136435 Human SwissProt: P23945 Human SwissProt: P35378 Mouse SwissProt: P35379 Sheep Unigene: 1428 Human Unigene: 57155 Mouse Unigene: 162843 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FSHR屬于G蛋白偶聯(lián)受體超家族中的糖蛋白亞家族成員，跨膜蛋白。人類的FSHR是由695個氨基酸組成的一條肽鏈。主要分布于睪丸支持細胞和卵巢顆粒細胞，成熟的FSHR蛋白分子質(zhì)量為：75kDa。 |
