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Rabbit Anti-Integrin Alpha V + Beta 3 (CD51+CD61)/Cy5 Conjugated antibody (bs-1310R-Cy5)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1310R-Cy5
英文名稱 Rabbit Anti-Integrin Alpha V + Beta 3 (CD51+CD61)/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的整合素αVβ3抗體
別    名 CD51 + CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v beta 3; ITGAV; ITGB3; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; VNRA; Antigen identified by monoclonal antibody L230; CD51 antigen; CD61 antigen; DKFZp686A08142; Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin alpha v; Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin beta chain beta 3; intregrin alpha v beta 3; ITGAV; MSK8; Platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets.
Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.

Subcellular Location:
Cell Membrane; single-pass type I membrane protein.

Database links:

Entrez Gene: 3685 Human

Entrez Gene: 3690 Human

Omim: 173470 Human

Omim: 193210 Human

SwissProt: P05106 Human

SwissProt: P06756 Human

Unigene: 218040 Human

Unigene: 436873 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

整合素αVβ3為二聚體的跨膜糖蛋白質(zhì),可以調(diào)節(jié)腫瘤細(xì)胞在多種細(xì)胞外基質(zhì)蛋白中的粘附和遷移,在被激活的內(nèi)皮細(xì)胞中有較高的表達(dá),并在新生血管生成過(guò)程中發(fā)揮優(yōu)勢(shì)。
整合素αVβ3在細(xì)胞外的信號(hào)傳入細(xì)胞內(nèi)調(diào)節(jié)細(xì)胞生長(zhǎng)、改變細(xì)胞形態(tài)、影響細(xì)胞運(yùn)動(dòng), 并在腫瘤侵襲和轉(zhuǎn)移的過(guò)程中起重要作用.整合素αVβ3是特異性表達(dá)在血管內(nèi)皮細(xì)胞表面的粘附因子。
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