| 產(chǎn)品編號(hào) | IHC0495H |
| 英文名稱 | Human ATG4C Ready-To-Use IHC Kit |
| 中文名稱 | 人自噬相關(guān)蛋白4C即用型免疫組化試劑盒 |
| 別 名 | ATG4C; APG4 autophagy 4 homolog C (S. cerevisiae); APG4 autophagy 4 homolog C; APG4 C; APG4-C; APG4C; ATG 4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); Atg4c; ATG4C_HUMAN; AUT (S. cerevisiae) like 1; cysteine endopeptidase; AUT like 1; cysteine |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. SWISS: Q96DT6 Gene ID: 84938 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human skeletal muscle tissue slide using IHC0495H (Human ATG4C IHC Kit).
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0495H (Human ATG4C IHC Kit).
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