| 產(chǎn)品編號 |
V7402-Bio |
| 英文名稱 |
CA125 Mouse mAb, Biotin conjugated
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| 中文名稱 |
Biotin標記的卵巢癌抗原單克隆抗體 |
| 別 名 |
CA 125; CA-125; CA125 ovarian cancer antigen; Cancer antigen 125; FLJ14303; MUC16_HUMAN; MUC 16; Mucin 16; MUC-16; Mucin 16 cell surface associated; Mucin16; Ovarian cancer related tumor marker CA125; Ovarian carcinoma antigen CA125; Ovarian cancer-related tumor marker CA125 |
| 克 隆 號 |
5B12 |
| 理論分子量 |
kDa |
| 檢測分子量 |
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| 緩 沖 液 |
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller “subunits” being described by some investigators.
CA125是與卵巢癌細胞相關的膜表面糖蛋白。在正常情況下卵巢細胞中無CA125抗原，但在經(jīng)期和孕期婦女的卵巢中發(fā)現(xiàn)存在由此種抗原。
該蛋白是上皮性卵巢癌尤其是漿液性腺癌的主要標記，也可用于其他惡性腫瘤的研究，如：乳腺癌、胰腺癌、肝癌和消化系統(tǒng)的腫瘤等。
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