| 產(chǎn)品編號(hào) | bsm-60742M |
| 英文名稱 | HDAC3 Recombinant Mouse mAb |
| 中文名稱 | 組蛋白去乙酰化酶3單克隆抗體 |
| 別 名 | RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3(HD3)(RPD3-2); histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 發(fā)育生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | A11D3 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500,IHC-P=1:100-500,IHC-F=1:400-800,IF=1:50,ICC/IF=1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HDAC3 |
| 亞 型 | IgG2b, Kappa |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | PBS, Glycerol, BSA. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]. SWISS: O15379 Gene ID: 8841 Database links: Entrez Gene: 8841 Human Entrez Gene: 15183 Mouse Omim: 605166 Human SwissProt: O15379 Human SwissProt: O88895 Mouse Unigene: 519632 Human Unigene: 20521 Mouse Unigene: 17284 Rat
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