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Oct 4 (1F4) Mouse mAb (bsm-52001M)  
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50ul/1580.00元
100ul/2500.00元
大包裝/詢價
產(chǎn)品編號 bsm-52001M
英文名稱 Oct 4 (1F4) Mouse mAb
中文名稱 胚胎干細胞關(guān)鍵蛋白單克隆抗體
別    名 MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; OCT3; Oct4; Octamer binding protein 3; Octamer-binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding transcription factor 3; Octamer-4; POU domain transcription factor OCT4; OTF3; OTF4; OTF 3; OTF 4; OTF-3; POU class 5 homeobox 1; POU domain, class 5, transcription factor 1; POU domain class 5 transcription factor 1; PO5F1_HUMAN; POU type homeodomain containing DNA binding protein; POU5F1.  
研究領(lǐng)域 細胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  干細胞  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  細胞類型標志物  表觀遺傳學(xué)  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 1F4
交叉反應(yīng) (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:500-2000,ICC/IF=1:100-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OCT4: 1-100/360 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.

Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Subunit:
Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2.

Subcellular Location:
Nucleus.Note=Expressed in a diffuse and slightly punctuate pattern.

Tissue Specificity:
Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

Post-translational modifications:
Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By similarity).
ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

Similarity:
Belongs to the POU transcription factor family. Class-5 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

SWISS:
Q01860

Gene ID:
5460

Database links:

Entrez Gene: 282316 Cow

Entrez Gene: 5460 Human

Entrez Gene: 18999 Mouse

Entrez Gene: 100127461 Pig

Entrez Gene: 294562 Rat

Omim: 164177 Human

SwissProt: O97552 Cow

SwissProt: Q01860 Human

SwissProt: P20263 Mouse

SwissProt: Q9TSV5 Pig

Unigene: 249184 Human

Unigene: 632482 Human

Unigene: 646545 Human

Unigene: 17031 Mouse

Unigene: 161748 Rat



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