| 產(chǎn)品編號 | bsm-33075M |
| 英文名稱 | CD2 Mouse mAb |
| 中文名稱 | CD2單克隆抗體 |
| 別 名 | CD2_HUMAN; T-cell surface antigen CD2; T cell surface antigen CD2; SRBC; Erythrocyte receptor; LFA-2; LFA2; LFA3 receptor; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD 2; CD2 antigen; CD2 molecule; |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞表面分子 t-淋巴細(xì)胞 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 5H3 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human CD2 protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016] Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Subunit: Interacts with CD2AP. Interacts with PSTPIP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: P06729 Gene ID: 914 Database links: Entrez Gene: 914 Human Entrez Gene: 12481 Mouse Omim: 186990 Human SwissProt: P06729 Human SwissProt: P08920 Mouse Unigene: 523500 Human Unigene: 22842 Mouse Unigene: 10328 Rat CD2分子又稱T11、綿羊紅細(xì)胞受體（ER）、淋巴細(xì)胞功能相關(guān)抗原2（LFA-2）和Leu5，是人T淋巴細(xì)胞表面的單鏈糖蛋白.CD2分子是分布于胸腺細(xì)胞及所有成熟T淋巴細(xì)胞和大部分自然殺傷細(xì)胞表面的特征性分化抗原。CD2具有調(diào)節(jié)T淋巴細(xì)胞分化、成熟、激活和凋亡等功能，CD2與LFA-3之間的粘附功能對于T淋巴細(xì)胞TCR識別外來抗原與APC細(xì)胞表面MHC抗原復(fù)合物、腫瘤抗原、病毒感染靶細(xì)胞以及同種異體抗原均有重要的輔助作用。 最近研究表明，CD48和CD59也是CD2的配體，參與T細(xì)胞的粘附和細(xì)胞間的相互作用,此外，CD2可以與其它膜分子如CD44、CD45的功能有關(guān)。CD2具有對T細(xì)胞的旁路激活途徑作用。 |
