| 產(chǎn)品編號 | bs-19325R |
| 英文名稱 | NPAS4 Rabbit pAb |
| 中文名稱 | 神經(jīng)細(xì)胞PAS結(jié)構(gòu)域蛋白4抗體 |
| 別 名 | bHLH PAS type transcription factor NXF; bHLHe79; bHLHe79; Class E basic helix-loop-helix protein 79; HLH-PAS transcription factor NXF; Le PAS; limbic enhanced PAS protein; neuronal PAS domain protein 4; Neuronal PAS domain-containing protein 4; Neuronal PAS4; NPAS4; NPAS4_HUMAN; NXF; PAS domain-containing protein 10; PASD10. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 87 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NPAS4: 1-100/802 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008] Function: Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNT. Subcellular Location: Nucleus. Tissue Specificity: Brain. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. SWISS: Q8IUM7 Gene ID: 266743 Database links: Entrez Gene: 266743 Human Entrez Gene: 225872 Mouse Entrez Gene: 724016 Zebrafish Omim: 608554 Human SwissProt: Q8IUM7 Human SwissProt: Q8BGD7 Mouse SwissProt: Q1ECW2 Zebrafish Unigene: 256036 Human Unigene: 287867 Mouse Unigene: 86654 Rat Unigene: 81110 Zebrafish |
