| 產(chǎn)品編號 | bs-18168R |
| 英文名稱 | Tollip Rabbit pAb |
| 中文名稱 | Toll蛋白相互作用蛋白抗體 |
| 別 名 | Adapter protein; FLJ33531; IL 1RAcPIP; IL1RAcPIP; TOLIP; TOLIP_HUMAN; Toll interacting protein; Toll-interacting protein; tollip. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Pig,Cow,Chicken,Dog,Horse,Xenopus laevis) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 30 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tollip: 101-200/274 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011] Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. Similarity: Belongs to the tollip family. Contains 1 C2 domain. Contains 1 CUE domain. SWISS: Q9H0E2 Gene ID: 54472 Database links: Entrez Gene: 54472 Human Entrez Gene: 423099 Chicken Entrez Gene: 54473 Mouse Entrez Gene: 336876 Zebrafish Omim: 606277 Human SwissProt: Q5ZK05 Chicken SwissProt: Q9H0E2 Human SwissProt: Q9QZ06 Mouse SwissProt: Q7ZV43 Zebrafish Unigene: 368527 Human Unigene: 103551 Mouse Unigene: 137040 Rat Unigene: 79855 Zebrafish |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tollip) Polyclonal Antibody, Unconjugated (bs-18168R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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