| 產(chǎn)品編號(hào) | bs-14416R |
| 英文名稱 | DPH3 Rabbit pAb |
| 中文名稱 | DPH3蛋白抗體 |
| 別 名 | CSL-type zinc finger-containing protein 2; Deafness locus putative guanine nucleotide exchange factor interacting protein 1; DelGEF-interacting protein 1; DELGIP; DelGIP1; DESR1; Diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1; DPH |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)菌及病毒 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 9.2 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPH3: 1-82/82 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. Similarity: Belongs to the DPH3 family. Contains 1 DPH-type zinc finger. SWISS: Q96FX2 Gene ID: 285381 Database links: Entrez Gene: 285381 Human Omim: 608959 Human SwissProt: Q96FX2 Human Unigene: 388087 Human |
