| 產(chǎn)品編號 | bs-14334R |
| 英文名稱 | DIXDC1 Rabbit pAb |
| 中文名稱 | 卷曲螺旋蛋白DIX1抗體 |
| 別 名 | CCD1; Ccd1Aalpha1L; Ccd1Abeta1L; Ccd1BalphaL; Ccd1BbetaL; Ccd1CL; Coiled coil DIX1; Coiled coil protein DIX1; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain containing 1; DIX domain containing protein 1; DIX domain-containing protein 1; DIXC1_HUMA |
| 研究領(lǐng)域 | 心血管 細胞生物 信號轉(zhuǎn)導(dǎo) 干細胞 激酶和磷酸酶 細胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 77 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DIXDC1: 51-150/683 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Subcellular Location: Cytoplasm; Cell junction; focal adhesion. Associated with actin stress fiber at the filament ends and Cytoplasm; cytosol. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. Tissue Specificity: Ubiquitously expressed with higher expression in cardiac and skeletal muscles. Post-translational modifications: Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. Similarity: Belongs to the DIXDC1 family. Contains 1 CH (calponin-homology) domain. Contains 1 DIX domain. SWISS: Q155Q3 Gene ID: 85458 Database links: Entrez Gene: 85458 Human Omim: 610493 Human SwissProt: Q155Q3 Human Unigene: 655626 Human |
