| 產(chǎn)品編號 | bs-13753R |
| 英文名稱 | Claudin 15 Rabbit pAb |
| 中文名稱 | 緊密連接蛋白15抗體 |
| 別 名 | Claudin-15; CLD15_HUMAN; CLDN15. |
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Specific References (2) | bs-13753R has been referenced in 2 publications.
[IF=8.786] Ying Xiao. et al. Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7.. FRONT IMMUNOL. 2022 Oct;13:1020902-1020902 WB ; Human.
[IF=4.718] Kline KT et al. Neonatal?Injury?Increases?Gut?Permeability?by?Epigenetically?Suppressing?E-Cadherin?in?Adulthood. J Immunol. 2020 Feb 15;204(4):980-989. WB ; Rat.
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| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 15: 101-180/228 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-15 is a 228 amino acid multi-pass membrane protein that belongs to the claudin family and plays an important role in cell-adhesion activity and tight junction-specific events. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subcellular Location: Cell junction, tight junction. Cell membrane. Similarity: Belongs to the claudin family. SWISS: P56746 Gene ID: 24146 Database links: Entrez Gene: 24146 Human SwissProt: P56746 Human Unigene: 38738 Human |
| 產(chǎn)品圖片 |
Sample:FHC(Human)cell Lysate at 40 ug
Primary: Anti-Claudin 15(bs-13753R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 22kD
Observed band size: 20kD
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