| 產(chǎn)品編號 | bs-11260R |
| 英文名稱 | SNIP1 Rabbit pAb |
| 中文名稱 | Smad核相互作用蛋白1抗體 |
| 別 名 | FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein(Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1(Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4(Pre mRNA splicing factor SRP75). |
| 研究領(lǐng)域 | 信號轉(zhuǎn)導(dǎo) 生長因子和激素 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SNIP1: 301-396/396 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle. Function: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Subunit: Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Subcellular Location: Nucleus. Tissue Specificity: Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle. Post-translational modifications: Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. DISEASE: Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]. A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. Similarity: Contains 1 FHA domain. SWISS: Q8TAD8 Gene ID: 79753 Database links: Entrez Gene: 79753 Human Entrez Gene: 76793 Mouse Omim: 608241 Human SwissProt: Q8TAD8 Human SwissProt: Q8BIZ6 Mouse |
