| 產(chǎn)品編號(hào) | bs-2128R |
| 英文名稱 | OST-beta Rabbit pAb |
| 中文名稱 | 有機(jī)溶質(zhì)轉(zhuǎn)運(yùn)蛋白OSTβ抗體 |
| 別 名 | organic solute transporter beta(Ostbeta); Organic solute transporter subunit beta; Ostbeta; Ost beta; OSTB; OSTB_HUMAN. |
 |
Specific References (6) | bs-2128R has been referenced in 6 publications.
[IF=6.876] Song Guochao. et al. Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. CLIN SCI. 2023 Apr;137(7):561-577 WB ; Mouse.
[IF=6.388] Fangle Liu. et al. Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways. PHYTOTHER RES. 2022 Aug;: WB ; Rat.
[IF=3.69] Meiqi Wang. et al. Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats. J Ethnopharmacol. 2021 Apr;270:113816 WB ; Rat.
[IF=3.628] Jing Zhao. et al. The choleretic role of tauroursodeoxycholic?acid exacerbates alpha-naphthylisothiocyanate?induced cholestatic liver injury through the FXR/BSEP pathway. J APPL TOXICOL. 2023 Feb;: WB ; Mouse.
[IF=3.448] Dolezelova E et al. High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice. Life Sci. 2019 Jul 9:116643. WB ; Mouse.
[IF=0] Stipanuk, Martha H., et al. "Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model." Taurine 10. Springer, Dordrecht, 2017. 475-495. WB ; Mouse.
|
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 14 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OST-beta: 1-35/128 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum. Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. Subunit: Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane. Subcellular Location: Cell membrane. Mainly restricted to the lateral and basal membranes of ileal enterocytes. Tissue Specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. Similarity: Belongs to the OST-beta family. SWISS: Q86UW2 Gene ID: 123264 Database links: UniProtKB/Swiss-Prot: Q86UW2.2 |
