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產(chǎn)品編號	bs-6700R
英文名稱	SRD5A2 Rabbit pAb
中文名稱	類固醇5α還原酶2抗體
別名	5 alpha SR2; EC; SR type 2; Steroid 5 alpha reductase 2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; SRD5A2; Steroid 5 alpha reductase 2; Steroid 5-alpha-reductase 2; Steroid-5-alpha-reductase, alpha polypeptide 2(3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); Type II 5-alpha reductase.
	Specific References (10) \| bs-6700R has been referenced in 10 publications. [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway. J Steroid Biochem. 2021 Nov;214:106001 WB,IHC ; Bovine. PubMed:10.1016/j.jsbmb.2021.106001 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-β/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041 WB ; Dog. PubMed:34864206 [IF=4.24] Tanaka, Sota, et al. "The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma." Molecular and Cellular Endocrinology (2014). IHC-P ; Human. PubMed:25475427 [IF=3.659] Lu, Shan. et al. An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification. Bmc Complem Altern M. 2022 Dec;22(1):1-20 WB ; Human. PubMed:35236335 [IF=3.415] Kumata H et al. Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.Hepatol Res. 2018 Nov;48(12):989-999. IHC-P ; Human. PubMed:29882386 [IF=2.984] Junjie Hu. et al. Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. Gene. 2021 Jul;790:145699 WB ; Sheep. PubMed:33964380 [IF=2.923] Hongwei Duan. et al. Melatonin regulates dihydrotestosterone formation via its membrane receptor in the epididymal epithelial cells of sheep. THERIOGENOLOGY. 2022 Dec;: WB ; Sheep. PubMed:36623430 [IF=2.775] Binghao Bao. et al. Zuogui Wan improves spermatogenesis of GC1-spg cells through modulating AR-related pathways. ANDROLOGIA. 2022 Apr 08 WB ; Mouse. PubMed:10.1111/and.14407 [IF=2.445] Song L et al. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages. Gen Comp Endocrinol. 2019 Aug 12:113245. WB&IHC-P ; Yak. PubMed:31415730 [IF=1.951] Jisheng Wang. et al. In vitro and in vivo investigation of the therapeutic mechanism of Lycium Chinense and Cuscutae Semen on oligoasthenozoospermia. 2021 Mar 05 WB ; Rat. PubMed:33666949
研究領(lǐng)域	細(xì)胞生物信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡細(xì)胞周期蛋白轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	(predicted: Human,Mouse,Rat,Pig,Horse)
產(chǎn)品應(yīng)用	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	28 kDa
檢測分子量
細(xì)胞定位	細(xì)胞漿細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SRD5A2: 201-254/254
亞型	IgG
純化方法	affinity purified by Protein A
緩沖液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產(chǎn)品介紹	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Subcellular Location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Expressed in high levels in the prostate and many other androgen-sensitive tissues. DISEASE: Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Similarity: Belongs to the steroid 5-alpha reductase family. SWISS: P31213 Gene ID: 6716 Database links: Entrez Gene: 403715 Dog Entrez Gene: 6716 Human Entrez Gene: 94224 Mouse Entrez Gene: 397048 Pig Entrez Gene: 64677 Rat Omim: 607306 Human SwissProt: P31213 Human SwissProt: Q3UTZ9 Mouse SwissProt: Q99N99 Mouse SwissProt: O18765 Pig SwissProt: P31214 Rat Unigene: 458345 Human Unigene: 38933 Mouse Unigene: 9938 Rat

	免疫組化常用試劑
	免疫印跡常用試劑
	各種標(biāo)記二抗

	1、抗體溶解方法
	2、抗體修復(fù)方式
	3、常用試劑的配制
	4、免疫組化操作步驟
	5、免疫組化問題解答
	6、Western Blotting 操作步驟
	7、Western Blotting 問題解答
	8、關(guān)于肽鏈的設(shè)計
	9、多肽的溶解與保存
	10、酶標(biāo)抗體效價測定程序

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