| 產(chǎn)品編號 | bs-5872R |
| 英文名稱 | plasma kallikrein B1 heavy chain Rabbit pAb |
| 中文名稱 | 血漿激肽釋放酶重鏈抗體 |
| 別 名 | Plasma Kallikrein 1B; Plasma kallikrein B1; EC 3.4.21.34; Fletcher factor; Kallikrein 3 plasma(Fletcher factor); kallikrein B plasma; Kallikrein B plasma(Fletcher factor) 1; Kallikrein B, plasma 1; Kininogenin; KLK3; KLKB1; KLKB1_HUMAN; Plasma kallikrein; Plasma prekallikrein; PPK; Prekallikrein; plasma kallikrein B1 heavy chain; Plasma kallikrein; Fletcher factor; Plasma kallikrein heavy chain. |
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Specific References (2) | bs-5872R has been referenced in 2 publications.
[IF=4.9] Benyamin et al. Identification of novel loci affecting circulating chromogranins and related peptides. (2017) Hum.Mol.Genet. 26:233-242 ICC ; Rat.
[IF=3.571] Zhang W et al. Theaflavin TF3 relieves hepatocyte lipid deposition through activating AMPK signaling pathway by targeting plasma kallikrein. J Agric Food Chem. 2020 Mar 4;68(9):2673-2683. WB ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 激酶和磷酸酶 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human plasma kallikrein B1 heavy chain: 451-550/638 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Subunit: Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds. Subcellular Location: Secreted. DISEASE: Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. SWISS: P03952 Gene ID: 3818 Database links: Entrez Gene: 3818 Human Omim: 229000 Human SwissProt: P03952 Human Unigene: 237642 Human Unigene: 9880 Rat |
| 產(chǎn)品圖片 |
Sample:
Hela(human)cell Lysate at 30 ug
Cerebrum(mouse) Lysate at 40 ug
K562(human)cell Lysate at 30 ug
liver(mouse) Lysate at 40 ug
Primary: Anti-plasma kallikrein B1 heavy chain (bs-5872R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41kD
Observed band size: 55 kD
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