| 產(chǎn)品編號(hào) | bs-4121R |
| 英文名稱 | Exendin 4 Rabbit pAb |
| 中文名稱 | GLP1類似蛋白Exendin4抗體 |
| 別 名 | Exendin 4; Exendin4; Exendin-4; EXE4_HELSU. |
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Specific References (1) | bs-4121R has been referenced in 1 publications.
[IF=10.317] Jong Youl Leeet al. Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity. Biomaterials
. 2020 Oct;257:120250. IHC, IF ; mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Gila monster lizard) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 4.3 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4: 1-39/39 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. Function: Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. Subcellular Location: Secreted. Tissue Specificity: Expressed by the venom gland. Similarity: Belongs to the glucagon family. Database links:
Exendin-4是從希拉毒蜥唾液中分離的一種多肽激素,由39個(gè)氨基酸殘基組成,與胰高血糖素樣肽1(GLP-1)有53%的同源性。Exendin-4具有高度的組織特異性,僅在希拉毒蜥的唾液腺中表達(dá), 具有促進(jìn)葡萄糖依賴性的胰島素分泌、促進(jìn)β細(xì)胞增殖、減慢胃排空、抑制食物攝取和減輕體重等作用。 腸促胰島素類似物（exendin-4，Ex-4）是從美洲一種毒蜥的唾液中分泌的胰升糖素樣肽-1（glucagon-like peptide-1，GLP-1）類似物，它具有促進(jìn)胰腺胰島素的分泌、增加胰島素敏感性及改善胰島細(xì)胞功能的作用，且不被二肽基肽酶Ⅳ（DPP-Ⅳ）分解，血漿半衰期較長(zhǎng)，因而在人類，對(duì)糖尿病治療應(yīng)用來說是穩(wěn)定、長(zhǎng)效的有治療前景的藥物。 鈍尾毒蜥 (Gila monster) |
