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Brucella Rabbit pAb (bs-2229R)  
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產(chǎn)品編號 bs-2229R
英文名稱 Brucella Rabbit pAb
中文名稱 布氏桿菌抗體
別    名 Brucella bacterial;  布魯氏菌; 布魯氏桿菌; 布魯氏桿菌病; 布魯氏病; 布魯氏病菌; 布氏桿菌菌體蛋白; 布病;
Specific References  (12)     |     bs-2229R has been referenced in 12 publications.
[IF=13.751] Fengguang Guo. et al. Live attenuated bacterium limits cancer resistance to CAR-T therapy by remodeling the tumor microenvironment. J Immunother Cancer. 2022 Jan;10(1):e003760  IF ;  Mouse.  
[IF=8.786] Stranahan Lauren W.. et al. Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice. FRONT IMMUNOL. 2022 Aug;0:4494  IHC ;  Mouse.  
[IF=8.146] Kelsey Michelle Wells. et al. Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense. ELIFE. 2022; 11: e73625  IF ;  null,Mouse.  
[IF=6.064] Martha E. Hensel. et al. Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection.. FRONT MICROBIOL. 2022 Oct;13:1029199-1029199  IHC ;  Mouse, Guinea pig.  
[IF=5.77] Charles R. Moley. et al. Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis. AM J PATHOL. 2023 May;:  IHC ;  Mouse.  
[IF=4.282] Hensel ME et al. Vaccine Candidate Brucella melitensis 16MΔvjbR Is Safe in a Pregnant Sheep Model and Confers Protection. mSphere. 2020 May 13;5(3):e00120-20.  IHC-P ;  Sheep.  
[IF=3.256] Khalaf OH et al. The NOD-scid IL2rγnull Mouse Model Is Suitable for the Study of Osteoarticular Brucellosis and Vaccine Safety. Infect Immun.?2019 May 21;87(6). pii: e00901-18.  IHC-P&IHF ;  Mouse.  
[IF=3.201] Martha E. Hensel. et al. Intratracheal Inoculation with Brucella melitensis in the Pregnant Guinea Pig Is an Improved Model for Reproductive Pathogenesis and Vaccine Studies. Infect Immun. 2020 Sep;88(10):e00204-20  IHC ;  Pig.  
[IF=3.143] Raquel M et al. Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MΔvjbR strain in GoatsVaccine.2021 Jan 15;39(3):617-625.  IHC ;  Goat.  
[IF=2.776] Stranahan LW et al. Characterization of Brucella canis infection in mice. PLoS One. 2019 Jun 20;14(6):e0218809.  IHC-P&iELISA ;  Mouse.  
[IF=2.495] Xin Hu. et al. The role of CXCR3 and its ligands expression in Brucellar spondylitis. Bmc Immunol. 2020 Dec;21(1):1-8  IHC ;  Human.  
[IF=2.02] Wareth, Gamal, et al. "Experimental infection of chicken embryos with recently described Brucella microti: Pathogenicity and pathological findings."Comparative Immunology, Microbiology and Infectious Diseases (2015).  IHC-P ;  Chicken.  
研究領(lǐng)域 微生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Brucella)
產(chǎn)品應(yīng)用 ELISA=1:1000-5000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 kDa
檢測分子量
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 whole cell protein of Brucella 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Brucella species are small, Gram-negative, facultative coccobacilli, most lacking a capsule, endospores, or native plasmids. They are intracellular within the host organism, and show environmental persistence outside the host. They survive extremes in temperature, pH, and humidity, and in frozen and aborted materials. They infect many species, but with some specificity.

布氏桿菌屬(Brucella)是一類革蘭氏陰性的短小桿菌,牛、羊、豬等動物最易感染,引起母畜傳染性流產(chǎn)。人類接觸帶菌動物或食用病畜及其乳制品,均可被感染。布氏桿菌病廣泛分布世界各地。我國部分地區(qū)曾有流行,現(xiàn)已基本控制。布氏桿菌也是帝國主義者列為失能性生物戰(zhàn)劑之一。布氏桿菌屬分為羊、牛、豬、鼠、綿羊及犬布氏桿菌6個種,20個生物型。中國流行的主要是羊(Br.melitensis)、牛(Br.Bovis)、豬(Br.suis)三種布氏桿菌,其中以羊布氏桿菌病最為多見.
布氏桿菌首先感染家畜。家畜臨床表現(xiàn)不明顯。但懷孕的母畜則極易引起流產(chǎn)或死胎,所排出的羊水、胎盤、分泌物中含大量布氏桿菌,特別有傳染力。而其皮毛,尿糞,奶液中均有此菌。排菌可長達(dá)三個月以上。
人通過與家畜的接觸,服用了污染的奶及畜肉,吸入了含菌的塵土或菌進(jìn)入眼結(jié)合膜等途徑,皆可遭受感染。發(fā)病年齡大多在30歲以上。
該菌自損傷的皮膚及粘膜或消化道,呼吸道進(jìn)入人體后,首先被吞噬細(xì)胞吞噬,進(jìn)入淋巴結(jié),有時可在其中存活并生長繁殖形成感染灶,約2~3周后可進(jìn)入血液循環(huán)產(chǎn)生菌血癥。繼之在網(wǎng)狀內(nèi)皮系統(tǒng)如肝,脾,骨髓內(nèi)生長形成新的感染病灶,并可多次反復(fù)沖破細(xì)胞進(jìn)入血循中,則再一次引起菌血癥和臨床急性癥狀,表現(xiàn)為平均2~3周的發(fā)燒期,每間隔約3天至兩周,發(fā)燒又反復(fù),產(chǎn)生波浪狀的熱型,故稱為波浪熱。
布氏桿菌含有內(nèi)毒素及菌體本身皆可引起人體的過敏,出現(xiàn)各種的變態(tài)反應(yīng)性病變。骨關(guān)節(jié)病變,多發(fā)生在半年左右,少數(shù)病例更早些。布氏桿菌骨髓炎是血源性布氏桿菌感染在骨關(guān)節(jié)的局部表現(xiàn)。任何骨均可受累,但以脊椎炎最為多見。關(guān)節(jié)的病變常侵犯大關(guān)節(jié),以髖關(guān)節(jié)炎最為常見。慢性病人可伴有其它多處的關(guān)節(jié)病變。但大多數(shù)發(fā)生在腰椎,少數(shù)發(fā)生在胸椎,胸腰段,骶椎或骶髂關(guān)節(jié)者。男性病人可有睪丸腫大,睪丸炎癥表現(xiàn)。
產(chǎn)品圖片
Measured by its binding ability in a indirect ELISA. Immobilized Brucella bacterial protein (Cat. bs-2229P) at 2 μg/mL (100 μL/well) can bind ? Rabbit Anti-Brucella Antibody, the EC50 is 61.32 ng/mL.
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