| 產(chǎn)品編號(hào) | bs-0093R |
| 英文名稱 | TNF beta Rabbit pAb |
| 中文名稱 | 腫瘤壞死因子β抗體 |
| 別 名 | TNF-beta; LTalpha; Coley’s toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT alpha; LT; LTA; Lymphotoxin alpha(TNF superfamily, member 1); Lymphotoxin alpha; Natural killer cytotoxic factor; Necrosin; NKCF; OTTHUMP00000037612; OTTHUMP00000037613; TNF B; TNF superfamily member 1; TNFbeta; TNFSF 1; TNFSF1; Tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNFB_HUMAN; TNF β; TNF-β. |
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Specific References (2) | bs-0093R has been referenced in 2 publications.
[IF=2.738] Liang Wang et al. Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis. Dis Markers. 2020 May 20;2020:2509454. IHC ; Human.
[IF=1.826] Fei W et al. The effects of aqueous extract of Maca on energy metabolism and immunoregulation. Eur J Med Res. 2020 Jun 29;25(1):24. WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNF beta: 91-205/205 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha. Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Subcellular Location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. DISEASE: Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae. Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. Similarity: Belongs to the tumor necrosis factor family. SWISS: P01374 Gene ID: 4049 Database links: Entrez Gene: 4049 Human Entrez Gene: 16992 Mouse Omim: 153440 Human SwissProt: P01374 Human SwissProt: P09225 Mouse Unigene: 36 Human Unigene: 87787 Mouse Unigene: 160577 Rat 生長因子和激素 腫瘤壞死因子-β（TNF β）是多功能細(xì)胞因子，又稱淋巴毒素(Lymphotoxin,LT)是由活化淋巴細(xì)胞所產(chǎn)生，它具有抗腫瘤、抗病毒、誘導(dǎo)成纖維細(xì)胞、B細(xì)胞和胸腺細(xì)胞的增殖、分化以及調(diào)節(jié)免疫功能等廣泛的生物學(xué)效應(yīng)。 |
