| 產(chǎn)品編號 | bs-0077R |
| 英文名稱 | VIP Rabbit pAb |
| 中文名稱 | 血管活性腸肽抗體 |
| 別 名 | Vasoactive Intestinal peptide; MGC13587; Peptide histidine methioninamide 27; PHM 27; PHM27; PHV42; VIP peptides precursor; PHI; Peptide Histidine Isoleucine; Vasoactive intestinal peptide; VIP_HUMAN. |
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Specific References (6) | bs-0077R has been referenced in 6 publications.
[IF=6.208] Zhiqiang Zhang. et al. Vasoactive Intestinal Peptide (VIP) Protects Nile Tilapia (Oreochromis niloticus) against Streptococcus agalatiae Infection. INT J MOL SCI. 2022 Jan;23(23):14895 WB ; Fish.
[IF=4.45] Wieck, Minna M., et al. "Human and murine tissue-engineered colon exhibit diverse neuronal subtypes and can be populated by enteric nervous system progenitor cells when donor colon is aganglionic." Tissue Engineering A (2015). IHC-P ;
[IF=3.508] Wieck et al. Human and Murine Tissue-Engineered Colon Exhibit Diverse Neuronal Subtypes and Can Be Populated by Enteric Nervous System Progenitor Cells When Donor Colon Is Aganglionic. (2016) Tissue.Eng.Part.A. 22:53-64 IHC-P ; Human.
[IF=3.411] Liu Dan. et al. RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway. Biomed Res Int. 2021;2021:9956078 IF ; human.
[IF=2.85] Liang et al. Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome. (2016) Gut.Liver. 10:382-90 IHC ; Human.
[IF=1.52] Liang Q et al. Evaluation of a modified rat model for functional dyspepsia.Saudi J Gastroenterol. 2018 Jul-Aug;24(4):228-235. WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Pig,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 3.3/18 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VIP: 125-152/170 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Growth Factor and Hormones VIP(Vasoactive Intestinal peptide) is a 28-amino acid peptide structurally related tosecretin. It was originally isolated from intestinal extracts and shown to be a potent vasodilator. Subsequent work demonstrated that VIP is very widely distributed in the peripheral and central nervous systems, and probably should not be considered a true GI hormone. A huge number of biological effects have been attributed to VIP. With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen. Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. PHM and PHV also cause vasodilation. Subcellular Location: Secreted. Similarity: Belongs to the glucagon family. SWISS: P01282 Gene ID: 7432 Database links: Entrez Gene: 7432 Human Entrez Gene: 22353 Mouse Omim: 192320 Human SwissProt: P01282 Human SwissProt: P32648 Mouse Unigene: 53973 Human Unigene: 98916 Mouse Unigene: 18675 Rat VIP是一個廣泛分布于中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)的神經(jīng)肽，他有較強的血管舒張作用、支氣管擴張作用、平滑肌松弛作用，具有很多免疫系統(tǒng)細(xì)胞的活性，是一個促分裂劑。 近年來研究表明，VIP也是一種生長因子,它對多種惡性腫瘤的發(fā)生、發(fā)展、增殖和分化起重要的促進作用，血管活性腸肽的神經(jīng)保護作用受到來自膠質(zhì)細(xì)胞的活性依賴的神經(jīng)營養(yǎng)因子釋放的調(diào)節(jié)。VIP和PACAP有很高的同源性。 |
| 產(chǎn)品圖片 |
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-VIP Polyclonal Antibody, Unconjugated (bs-0077R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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