| 產(chǎn)品編號 | bs-1175R |
| 英文名稱 | SHBG Rabbit pAb |
| 中文名稱 | 性激素結(jié)合球蛋白抗體 |
| 別 名 | Sex Hormone Binding Globulin; ABP; Androgen binding protein; MGC126834; MGC138391; SBP; Sex steroid binding protein; SHBG; TEBG; Testis specific androgen binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testost |
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Specific References (2) | bs-1175R has been referenced in 2 publications.
[IF=7.31] Longfei Xiao. et al. Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway. OXID MED CELL LONGEV. 2023;2023:1708251 IF ; Pig.
[IF=4.292] Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-β/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041 IF ; Dog.
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| 研究領(lǐng)域 | 腫瘤 生長因子和激素 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SHBG: 301-402/402 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity. Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. Subunit: Homodimer. Subcellular Location: Secreted . Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. Tissue Specificity: Isoform 1 and isoform 2 are present in liver and testis. Post-translational modifications: Variant Asn-356 contains one N-linked (GlcNAc...) at position 356. Similarity: Contains 2 laminin G-like domains. SWISS: P04278 Gene ID: 6462 Database links: Entrez Gene: 6462 Human Omim: 182205 Human SwissProt: P04278 Human Unigene: 632235 Human 性激素結(jié)合球蛋白(SHBG),又稱睪酮—雌二醇結(jié)合球蛋白。 SHBG是一運輸性激素的載體，它在性激素人作用過程中以及在各種生理病理情況下都有一定的變化和意義。 SHBG是由母體肝臟產(chǎn)生的循環(huán)類固醇類結(jié)合球蛋白，執(zhí)行載體蛋白的功能，胰島素是肝臟合成SHBG的強(qiáng)大的抑制因子，胰島素抑制效應(yīng)的主要作用點在于競爭性刺激肝臟SHBG的產(chǎn)生，因而SHBG減少是高胰島素血癥、胰島素抵抗的標(biāo)志。 |
| 產(chǎn)品圖片 |
Tissue/cell: rat uterus tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SHBG Polyclonal Antibody, Unconjugated(bs-1175R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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