| 產(chǎn)品編號(hào) | bs-0337R |
| 英文名稱 | Myelin Protein Zero Rabbit pAb |
| 中文名稱 | 外周髓磷脂P0蛋白/P0蛋白抗體 |
| 別 名 | peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN. |
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Specific References (6) | bs-0337R has been referenced in 6 publications.
[IF=10.76] Schulz, Alexander, et al. "The importance of nerve microenvironment for schwannoma development." Acta Neuropathologica (2016): 1-19. IHC-P ; Mouse.
[IF=9.91] Schulz, Alexander, et al. ?Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling.? Brain (2013): awt327 IHC-P ; Human.
[IF=6] R?hr, Dominik, et al. "Sodium‐dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation." Glia (2017). WB, IF(ICC) ; Mouse.
[IF=4.73] Erdal Ayhan I?ik. et al. Use of Erythropoietin and Fibrin Glue Mixture for Peripheral Nerve Repair. Plast Reconstr Surg. 2022 Feb;149(2):395-403 IHC ; Rat.
[IF=3.73] Li, Junhui, et al. "Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia." PLoS One 6.2 (2011): e17385. IHC-P ; Human.
[IF=2.27] Chitose, Shun‐ichi, et al. "Recurrent laryngeal nerve regeneration using an oriented collagen scaffold containing Schwann cells." The Laryngoscope (2016). IHC-P ; Dog.
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| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 24 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P0 protein: 175-248/248 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the gene encoding Myelin protein-zero (MPZ) is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of ~28kDa, Myelin protein-zero is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein, myelin proteolipid protein and myelin-associated glycoprotein. Subunit: Homodimer and homotetramer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Found only in peripheral nervous system Schwann cells. Similarity: Belongs to the myelin P0 protein family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: P25189 Gene ID: 4359 Database links: Entrez Gene: 4359 Human Entrez Gene: 17528 Mouse Omim: 159440 Human SwissProt: P25189 Human SwissProt: P27573 Mouse Unigene: 591486 Human Unigene: 93883 Human Unigene: 9986 Mouse UniProtKB/Swiss-Prot: P25189.1
成熟的周圍神經(jīng)系統(tǒng)髓鞘主要的蛋白為P0蛋白，分子量28KDa，它具有單個(gè)跨膜區(qū)，是IgG超家族的成員之一。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Spinal cord (Mouse) Lysate at 40 ug
Lane 2: Spinal cord (Rat) Lysate at 40 ug
Lane 3: Adipose (Mouse) Lysate at 40 ug
Lane 4: Adipose (Rat) Lysate at 40 ug
Primary: Anti-Myelin Protein Zero (bs-0337R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 28 kD
Observed band size: 28 kD
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